PSYCHOLOGICAL TREATMENT OF DEPRESSION IN COLLEGE STUDENTS: A METAANALYSIS.

Pim Cuijpers, Ioana A Cristea, David D Ebert, Hans M Koot, Randy P Auerbach, Ronny Bruffaerts, Ronald C Kessler
Author Information
  1. Pim Cuijpers: Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  2. Ioana A Cristea: Department of Clinical Psychology and Psychotherapy, Babes-Bolyai University, Cluj-Napoca, Romania.
  3. David D Ebert: Department of Psychology, Clinical Psychology and Psychotherapy, Friedrich-Alexander University Nuremberg-Erlangen, Erlangen, Germany.
  4. Hans M Koot: Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  5. Randy P Auerbach: Department of Psychiatry, Harvard Medical School, Center for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, Massachusetts.
  6. Ronny Bruffaerts: Universitair Psychiatrisch Centrum - KU Leuven, Kortenberg, Belgium.
  7. Ronald C Kessler: Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts.

Abstract

BACKGROUND: Expanded efforts to detect and treat depression among college students, a peak period of onset, have the potential to bear high human capital value from a societal perspective because depression increases college withdrawal rates. However, it is not clear whether evidence-based depression therapies are as effective in college students as in other adult populations. The higher levels of cognitive functioning and IQ and higher proportions of first-onset cases might lead to treatment effects being different among college students relative to the larger adult population.
METHODS: We conducted a metaanalysis of randomized trials comparing psychological treatments of depressed college students relative to control groups and compared effect sizes in these studies to those in trials carried out in unselected populations of depressed adults.
RESULTS: The 15 trials on college students satisfying study inclusion criteria included 997 participants. The pooled effect size of therapy versus control was g = 0.89 (95% CI: 0.66∼1.11; NNT = 2.13) with moderate heterogeneity (I(2) = 57; 95% CI: 23∼72). None of these trials had low risk of bias. Effect sizes were significantly larger when students were not remunerated (e.g. money, credit), received individual versus group therapy, and were in trials that included a waiting list control group. No significant difference emerged in comparing effect sizes among college students versus adults either in simple mean comparisons or in multivariate metaregression analyses.
CONCLUSIONS: This metaanalysis of trials examining psychological treatments of depression in college students suggests that these therapies are effective and have effect sizes comparable to trials carried out among depressed adults.

Keywords

References

  1. J Psychiatr Res. 2012 Nov;46(11):1456-63 [PMID: 22939979]
  2. Br J Psychiatry. 1984 Apr;144:400-6 [PMID: 6372925]
  3. J Adolesc Health. 2010 Jan;46(1):3-10 [PMID: 20123251]
  4. Psychol Med. 2012 Mar;42(3):485-95 [PMID: 21740624]
  5. BMJ. 2007 Nov 3;335(7626):914-6 [PMID: 17974687]
  6. Am J Psychiatry. 1979 Apr;136(4B):555-8 [PMID: 371421]
  7. J Consult Clin Psychol. 2009 Aug;77(4):775-87 [PMID: 19634969]
  8. Clin Psychol Psychother. 2012 Mar-Apr;19(2):159-69 [PMID: 22337508]
  9. J Consult Clin Psychol. 1986 Apr;54(2):196-202 [PMID: 3700806]
  10. BMJ. 2000 Dec 9;321(7274):1450-4 [PMID: 11110739]
  11. J Consult Clin Psychol. 1979 Apr;47(2):413-5 [PMID: 469095]
  12. Am J Orthopsychiatry. 2006 Apr;76(2):226-37 [PMID: 16719642]
  13. Behav Res Ther. 2014 Apr;55:48-53 [PMID: 24655464]
  14. Int J Neuropsychopharmacol. 2010 Feb;13(1):31-44 [PMID: 19341510]
  15. PLoS One. 2014;9(10):e109789 [PMID: 25333885]
  16. Am J Psychiatry. 1995 Jul;152(7):1026-32 [PMID: 7793438]
  17. Depress Anxiety. 2012 Oct;29(10):855-64 [PMID: 22815247]
  18. Psychol Med. 2010 Dec;40(12):1943-57 [PMID: 20406528]
  19. Depress Anxiety. 2012 Feb;29(2):102-10 [PMID: 22495940]
  20. Psychother Psychosom. 2009;78(5):275-84 [PMID: 19602916]
  21. Am J Psychiatry. 2000 Jun;157(6):940-7 [PMID: 10831474]
  22. Lancet. 2009 Aug 22;374(9690):628-34 [PMID: 19700005]
  23. J Consult Clin Psychol. 1986 Jun;54(3):390-4 [PMID: 3722569]
  24. Acta Psychiatr Scand. 1983 May;67(5):319-32 [PMID: 6869040]
  25. J Clin Psychol. 1987 Mar;43(2):227-31 [PMID: 3553244]
  26. Health Technol Assess. 2000;4(19):1-83 [PMID: 11086269]
  27. J Affect Disord. 2009 Oct;117(3):180-5 [PMID: 19178949]
  28. Depress Anxiety. 2002;16(3):114-7 [PMID: 12415535]
  29. J Med Internet Res. 2008;10(4):e44 [PMID: 19033149]
  30. J Consult Clin Psychol. 2006 Aug;74(4):658-70 [PMID: 16881773]
  31. J R Coll Gen Pract. 1985 May;35(274):239-42 [PMID: 4020747]
  32. MD Comput. 1991 Mar-Apr;8(2):98-102 [PMID: 2038242]
  33. Br J Psychiatry. 2014 Mar;204(3):222-33 [PMID: 24357574]
  34. Biometrics. 2000 Jun;56(2):455-63 [PMID: 10877304]
  35. J Ment Health Policy Econ. 2005 Sep;8(3):145-51 [PMID: 16278502]
  36. Iran Red Crescent Med J. 2013 Feb;15(2):142-6 [PMID: 23682326]
  37. J Consult Clin Psychol. 1989 Jun;57(3):408-13 [PMID: 2738213]
  38. J Affect Disord. 2012 Dec 15;142(1-3):283-9 [PMID: 22840618]
  39. Arch Gen Psychiatry. 1989 Nov;46(11):971-82; discussion 983 [PMID: 2684085]
  40. J Clin Psychiatry. 2012 Jan;73(1):66-73 [PMID: 22152401]
  41. Br J Psychiatry. 1997 Aug;171:131-4 [PMID: 9337947]
  42. Arch Gen Psychiatry. 1999 May;56(5):431-7 [PMID: 10232298]
  43. JAMA. 2003 Jun 18;289(23):3117-24 [PMID: 12813117]
  44. Aust N Z J Psychiatry. 2006 Aug;40(8):613-5 [PMID: 16866755]
  45. BMJ. 2003 Sep 6;327(7414):557-60 [PMID: 12958120]
  46. Asian J Psychiatr. 2011 Jun;4(2):125-8 [PMID: 23051078]
  47. J Consult Clin Psychol. 1984 Oct;52(5):774-83 [PMID: 6501663]
  48. Issues Ment Health Nurs. 2009 Mar;30(3):188-96 [PMID: 19291496]
  49. Aust N Z J Psychiatry. 2009 Jun;43(6):571-8 [PMID: 19440890]
  50. J Clin Psychol. 1980 Apr;36(2):534-43 [PMID: 7372828]
  51. J Affect Disord. 2014 Mar;156:224-7 [PMID: 24274963]
  52. Biol Psychiatry. 2006 Jun 1;59(11):990-6 [PMID: 16368078]
  53. Cogn Behav Ther. 2014;43(4):289-98 [PMID: 24911260]
  54. J Affect Disord. 2013 May 15;148(1):1-11 [PMID: 23246209]
  55. Arch Gen Psychiatry. 1961 Jun;4:561-71 [PMID: 13688369]
  56. Acta Psychiatr Scand. 2014 Sep;130(3):181-92 [PMID: 24697518]
  57. PLoS One. 2012;7(5):e38021 [PMID: 22741027]
  58. PLoS Med. 2013;10(9):e1001518 [PMID: 24086114]
  59. BMJ. 1995 Feb 18;310(6977):441-5 [PMID: 7873952]
  60. Psychol Med. 2006 Jan;36(1):15-26 [PMID: 16356293]
  61. J Fam Pract. 1997 Mar;44(3):293-8 [PMID: 9071250]
  62. J Affect Disord. 2013 Jun;148(2-3):331-7 [PMID: 23357657]
  63. J Med Internet Res. 2013;15(5):e101 [PMID: 23711740]
  64. J Consult Clin Psychol. 1977 Aug;45(4):543-51 [PMID: 886034]
  65. Psychol Rep. 2004 Jun;94(3 Pt 1):785-92 [PMID: 15217028]
  66. Aust N Z J Psychiatry. 2008 Aug;42(8):702-11 [PMID: 18622778]
  67. Br J Psychiatry. 2005 Nov;187:456-61 [PMID: 16260822]
  68. J Nerv Ment Dis. 2011 May;199(5):301-8 [PMID: 21543948]
  69. Early Interv Psychiatry. 2010 May;4(2):132-42 [PMID: 20536969]
  70. BMC Psychiatry. 2008;8:36 [PMID: 18485191]
  71. J Nurs Scholarsh. 2000;32(2):145-51 [PMID: 10887713]
  72. Arch Gen Psychiatry. 2005 Apr;62(4):409-16 [PMID: 15809408]
  73. PLoS One. 2011;6(6):e21274 [PMID: 21712998]
  74. Behav Res Ther. 2010 May;48(5):368-76 [PMID: 20152960]
  75. BMJ. 1992 Apr 4;304(6831):883-7 [PMID: 1392754]
  76. J Consult Clin Psychol. 2008 Dec;76(6):909-22 [PMID: 19045960]
  77. PLoS One. 2012;7(5):e36905 [PMID: 22615841]
  78. World Psychiatry. 2014 Oct;13(3):288-95 [PMID: 25273302]
  79. J Clin Psychol. 1979 Jan;35(1):166-75 [PMID: 422720]
  80. Behav Res Ther. 2011 Jan;49(1):62-7 [PMID: 21074752]
  81. Psychother Psychosom. 2005;74(1):43-50 [PMID: 15627856]
  82. Psychol Rep. 1995 Oct;77(2):403-20 [PMID: 8559866]
  83. J Psychiatr Res. 2013 Mar;47(3):391-400 [PMID: 23260171]
  84. Cogn Behav Ther. 2011;40(4):251-66 [PMID: 22060248]
  85. J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 [PMID: 14399272]
  86. PLoS One. 2010;5(6):e10939 [PMID: 20544030]
  87. PLoS One. 2013;8(8):e70086 [PMID: 23990896]
  88. Br J Psychiatry. 2011 Jan;198(1):66-72 [PMID: 21200079]
  89. J Consult Clin Psychol. 1992 Feb;60(1):94-103 [PMID: 1556292]
  90. J Affect Disord. 2014 Jan;152-154:262-7 [PMID: 24140226]
  91. Arch Gen Psychiatry. 1996 Oct;53(10):913-9 [PMID: 8857868]
  92. J Consult Clin Psychol. 1995 Aug;63(4):644-50 [PMID: 7673542]
  93. Behav Res Ther. 2007 Jun;45(6):1111-26 [PMID: 17074301]
  94. Am J Psychiatry. 2005 Jun;162(6):1158-64 [PMID: 15930065]

Grants

  1. K23 MH097786/NIMH NIH HHS

MeSH Term

Adolescent
Adult
Depressive Disorder
Female
Humans
Male
Psychotherapy
Students
Universities

Word Cloud

Created with Highcharts 10.0.0collegestudentstrialsdepressionamongeffectsizestherapymetaanalysisdepressedcontroladultsversus=therapieseffectiveadultpopulationshighercognitiverelativelargercomparingpsychologicaltreatmentscarriedincludedg095%CI:2groupBACKGROUND:ExpandedeffortsdetecttreatpeakperiodonsetpotentialbearhighhumancapitalvaluesocietalperspectiveincreaseswithdrawalratesHoweverclearwhetherevidence-basedlevelsfunctioningIQproportionsfirst-onsetcasesmightleadtreatmenteffectsdifferentpopulationMETHODS:conductedrandomizedgroupscomparedstudiesunselectedRESULTS:15satisfyingstudyinclusioncriteria997participantspooledsize8966∼111NNT13moderateheterogeneity5723∼72NonelowriskbiasEffectsignificantlyremuneratedemoneycreditreceivedindividualwaitinglistsignificantdifferenceemergedeithersimplemeancomparisonsmultivariatemetaregressionanalysesCONCLUSIONS:examiningsuggestscomparablePSYCHOLOGICALTREATMENTOFDEPRESSIONINCOLLEGESTUDENTS:METAANALYSISbehavioralactivationbehaviorpsychotherapy

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