OpenLB
Open Library of Bioscience
Advanced Search
Viruses
Dec 07, 2015;7 (12): 6371-86.

From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis.

Eléonore Pérès, Eugénie Bagdassarian, Sébastien This, Julien Villaudy, Dominique Rigal, Louis Gazzolo, Madeleine Duc Dodon
Author Information
  1. Eléonore Pérès: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. eleonore.peres@ens-lyon.fr.
  2. Eugénie Bagdassarian: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. eugenie.bagdassarian@gmail.com.
  3. Sébastien This: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. sebastien.this@ens-lyon.fr.
  4. Julien Villaudy: AIMM Therapeutics, Meibergdreef 59, 1105 BA Amsterdam Zuidoost, The Netherlands. jvillaudy@aimmtherapeutics.com.
  5. Dominique Rigal: Etablissement français du sang, 69007 Lyon, France. dominique.rigal@efs-sante.fr.
  6. Louis Gazzolo: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. louis.gazzolo@ens-lyon.fr.
  7. Madeleine Duc Dodon: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. mducdodo@ens-lyon.fr.
PMID: 26690200 DOI: 10.3390/v7122944

Abstract

The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed.

Keywords

HTLV-1 adult T cell leukemia/lymphoma humanized mouse models oncogenesis

References

  1. Nature. 1970 Jun 27;226(5252):1209-11 [PMID: 4316300]
  2. Int Immunol. 2012 Apr;24(4):243-52 [PMID: 22402880]
  3. Eur J Immunol. 2009 Jul;39(7):1700-12 [PMID: 19582737]
  4. Vet Pathol. 2009 Sep;46(5):1003-14 [PMID: 19429977]
  5. J Exp Med. 1990 Oct 1;172(4):1055-63 [PMID: 2212942]
  6. J Gen Virol. 2011 Jun;92(Pt 6):1458-1466 [PMID: 21325484]
  7. J Virol. 1996 Jun;70(6):4038-44 [PMID: 8648741]
  8. Nat Rev Immunol. 2012 Nov;12(11):786-98 [PMID: 23059428]
  9. Arch Virol. 2014 Jul;159(7):1849-56 [PMID: 24818712]
  10. Front Microbiol. 2013 Mar 08;4:49 [PMID: 23483782]
  11. Med Sci (Paris). 2012 Jan;28(1):63-8 [PMID: 22289832]
  12. Virology. 1998 Sep 1;248(2):332-41 [PMID: 9721242]
  13. Blood. 2008 May 15;111(10):5047-53 [PMID: 18094326]
  14. Retrovirology. 2011 Mar 17;8:19 [PMID: 21414204]
  15. Blood. 2012 Jan 12;119(2):434-44 [PMID: 22123848]
  16. Nat Biotechnol. 2014 Apr;32(4):364-72 [PMID: 24633240]
  17. PLoS Pathog. 2011 Feb 10;7(2):e1001274 [PMID: 21347344]
  18. Cancer Sci. 2015 Apr;106(4):344-51 [PMID: 25613789]
  19. Blood. 2008 Nov 1;112(9):3788-97 [PMID: 18689544]
  20. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13224-9 [PMID: 21788504]
  21. Cancer Res. 2014 Jan 1;74(1):188-200 [PMID: 24177179]
  22. Nat Immunol. 2007 Dec;8(12):1313-23 [PMID: 17982459]
  23. J Exp Med. 2010 Dec 20;207(13):2785-92 [PMID: 21135137]
  24. Virology (Auckl). 2013 Nov 18;4:49-59 [PMID: 25512694]
  25. Cancer Sci. 2005 Aug;96(8):527-33 [PMID: 16108835]
  26. Blood. 2015 Jun 4;125(23):3527-35 [PMID: 25847015]
  27. Science. 1983 May 20;220(4599):868-71 [PMID: 6189183]
  28. J Clin Exp Hematop. 2010;50(1):9-25 [PMID: 20505272]
  29. Retrovirology. 2007 Dec 13;4:92 [PMID: 18078517]
  30. J Immunol Methods. 2014 Aug;410:3-17 [PMID: 24607601]
  31. Curr Top Microbiol Immunol. 2008;324:53-76 [PMID: 18481452]
  32. Cell Mol Immunol. 2012 May;9(3):208-14 [PMID: 22327211]
  33. Front Microbiol. 2012 Aug 31;3:320 [PMID: 22969759]
  34. Viruses. 2011 Jun;3(6):794-810 [PMID: 21994754]
  35. Science. 2004 Apr 2;304(5667):104-7 [PMID: 15064419]
  36. Leuk Res Treatment. 2012;2012:391953 [PMID: 23259066]
  37. Int J Cancer. 2007 Nov 15;121(10):2205-11 [PMID: 17657714]
  38. Science. 1990 Feb 2;247(4942):564-6 [PMID: 2300816]
  39. Blood. 2009 Feb 12;113(7):1493-500 [PMID: 18971418]
  40. Blood. 2015 Aug 27;126(9):1095-105 [PMID: 26063164]
  41. Blood. 2011 Mar 31;117(13):3575-84 [PMID: 21245486]
  42. Blood. 2005 Sep 1;106(5):1565-73 [PMID: 15920010]
  43. Blood. 2009 Mar 19;113(12):2755-64 [PMID: 19064727]
  44. Nature. 1970 Jun 27;226(5252):1211-3 [PMID: 4316301]
  45. FEBS Lett. 2004 Mar 26;562(1-3):165-70 [PMID: 15044019]
  46. Vet Pathol. 2010 Jul;47(4):677-89 [PMID: 20442421]
  47. Nat Rev Cancer. 2007 Apr;7(4):270-80 [PMID: 17384582]
  48. Cancer Res. 2015 Oct 1;75(19):4143-52 [PMID: 26383166]
  49. Trends Microbiol. 2015 Jun;23(6):367-75 [PMID: 25701112]
  50. J Virol. 1989 Jul;63(7):3185-9 [PMID: 2724422]
  51. Virology. 1993 Nov;197(1):196-204 [PMID: 8212554]
  52. Science. 1987 Sep 11;237(4820):1324-9 [PMID: 2888190]
  53. Oncogene. 2011 Mar 24;30(12):1379-89 [PMID: 21119600]
  54. J Virol. 2002 Dec;76(24):12813-22 [PMID: 12438606]
  55. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9 [PMID: 6261256]
  56. Cell. 2013 Sep 12;154(6):1370-9 [PMID: 23992847]
  57. Clin Immunol. 2010 Apr;135(1):84-98 [PMID: 20096637]
  58. Immunity. 1995 Mar;2(3):223-38 [PMID: 7697543]
  59. Oncogene. 2005 Sep 5;24(39):6058-68 [PMID: 16155612]
  60. Viruses. 2011 Jun;3(6):829-57 [PMID: 21994756]
  61. Nat Med. 2006 Nov;12(11):1316-22 [PMID: 17057712]
  62. Retrovirology. 2010 Feb 04;7:8 [PMID: 20132553]
  63. Leuk Res. 2002 Jun;26(6):561-7 [PMID: 12007504]
  64. Cancer Sci. 2010 Jan;101(1):224-30 [PMID: 19799612]
  65. J Immunol. 1995 Jan 1;154(1):180-91 [PMID: 7995938]
  66. PLoS Pathog. 2013 Sep;9(9):e1003630 [PMID: 24068936]
  67. Blood. 2009 Sep 24;114(13):2709-20 [PMID: 19584402]
  68. Annu Rev Immunol. 2013;31:635-674 [PMID: 23330956]
  69. J Immunol. 2009 Oct 1;183(7):4782-91 [PMID: 19748990]
  70. Cancer Lett. 2012 Apr 28;317(2):218-25 [PMID: 22138435]
  71. Best Pract Res Clin Haematol. 2016 Mar;29(1):133 [PMID: 27742067]
  72. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):720-5 [PMID: 16407133]
  73. Leukemia. 2005 Aug;19(8):1384-90 [PMID: 15959532]
  74. Blood. 2012 Jul 19;120(3):572-80 [PMID: 22589473]
  75. Nature. 1983 Feb 10;301(5900):527-30 [PMID: 6823332]
  76. Cancer Sci. 2012 Jan;103(1):100-6 [PMID: 21951590]
  77. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13022-7 [PMID: 20615947]
  78. Oncogene. 2005 Sep 5;24(39):5931-7 [PMID: 16155600]
  79. PLoS Pathog. 2015 Aug 21;11(8):e1005120 [PMID: 26296091]
  80. Nature. 1988 Sep 15;335(6187):256-9 [PMID: 2970594]
  81. Front Biosci (Schol Ed). 2009 Jun 01;1(1):194-204 [PMID: 19482695]
  82. J Virol. 2007 Feb;81(4):1543-53 [PMID: 17151132]
  83. Carcinogenesis. 2013 Nov;34(11):2664-72 [PMID: 23784080]
  84. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1057-61 [PMID: 7862633]
  85. Nat Med. 2006 Apr;12(4):466-72 [PMID: 16550188]
  86. Genet Res. 1966 Dec;8(3):295-309 [PMID: 5980117]
  87. Viruses. 2011 Jun;3(6):886-900 [PMID: 21994759]
  88. Leukemia. 2004 Aug;18(8):1357-63 [PMID: 15190257]
  89. PLoS Pathog. 2011 Sep;7(9):e1002231 [PMID: 21909275]
  90. Blood. 2014 Jan 16;123(3):346-55 [PMID: 24196073]
  91. Retrovirology. 2005 Mar 02;2:16 [PMID: 15743528]
  92. Virology. 2013 Jan 5;435(1):14-28 [PMID: 23217612]

MeSH Term

Animals
Disease Models, Animal
Host-Pathogen Interactions
Human T-lymphotropic virus 1
Humans
Leukemia-Lymphoma, Adult T-Cell
Mice
Mice, SCID
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0HTLV-1modelshumanTcellleukemia/lymphomaMousepathogenesismousefirstdiscoveredretrovirusHumanT-LymphotropicVirustype1responsibleaggressiveformrecapitulatingleukemogenesisprocesshelpfulunderstandingmechanismsunderlyingretroviral-induceddiseasereviewwillfocusrecentadvancesgenerationimmunodeficienthemato-lymphoidsystemmiceparticularemphasisdevelopmentHTLV-1-mediatedpresentlimitationschallengesyetaddressedImmunodeficiencyHumanization:ContributionModelsExploreLeukemogenesisadulthumanizedoncogenesis

Similar Articles

Cited By