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Dec 14, 2015;7 (12): 6613-30.

Innate Immunity and Immune Evasion by Enterovirus 71.

Prabuddha S Pathinayake, Alan C-Y Hsu, Peter A B Wark
Author Information
  1. Prabuddha S Pathinayake: Priority Research Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, New South Wales 2305, Australia. prabuddha.pathinayake@uon.edu.au.
  2. Alan C-Y Hsu: Priority Research Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, New South Wales 2305, Australia. alan.hsu@newcastle.edu.au.
  3. Peter A B Wark: Priority Research Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, New South Wales 2305, Australia. peter.wark@hnehealth.nsw.gov.au.
PMID: 26694447 DOI: 10.3390/v7122961

Abstract

Enterovirus 71 (EV71) is a major infectious disease affecting millions of people worldwide and it is the main etiological agent for outbreaks of hand foot and mouth disease (HFMD). Infection is often associated with severe gastroenterological, pulmonary, and neurological diseases that are most prevalent in children. Currently, no effective vaccine or antiviral drugs exist against EV71 infection. A lack of knowledge on the molecular mechanisms of EV71 infection in the host and the virus-host interactions is a major constraint to developing specific antiviral strategies against this infection. Previous studies have identified and characterized the function of several viral proteins produced by EV71 that interact with the host innate immune proteins, including type I interferon signaling and microRNAs. These interactions eventually promote efficient viral replication and increased susceptibility to the disease. In this review we discuss the functions of EV71 viral proteins in the modulation of host innate immune responses to facilitate viral replication.

Keywords

Enterovirus 71 Interferon antagonist J0101 innate immunity

References

  1. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1828-33 [PMID: 16446426]
  2. Lancet Infect Dis. 2010 Nov;10(11):778-90 [PMID: 20961813]
  3. J Biomed Sci. 2004 Mar-Apr;11(2):239-48 [PMID: 14966374]
  4. J Virol. 1996 Dec;70(12):8444-50 [PMID: 8970966]
  5. Cell Microbiol. 2006 Jun;8(6):907-22 [PMID: 16681834]
  6. Nat Rev Immunol. 2014 Jan;14(1):36-49 [PMID: 24362405]
  7. Cell Host Microbe. 2011 Jan 20;9(1):58-69 [PMID: 21238947]
  8. Virology. 1994 Feb;198(2):741-5 [PMID: 8291255]
  9. Mitochondrion. 2011 Jan;11(1):1-12 [PMID: 20813204]
  10. Clin Exp Immunol. 2014 Sep;177(3):687-95 [PMID: 24773058]
  11. Vaccine. 2007 Apr 20;25(16):3175-8 [PMID: 17280757]
  12. Lancet Neurol. 2010 Nov;9(11):1097-105 [PMID: 20965438]
  13. BMC Struct Biol. 2008;8:11 [PMID: 18307765]
  14. Sultan Qaboos Univ Med J. 2015 Feb;15(1):e9-e21 [PMID: 25685392]
  15. PLoS Pathog. 2013 Mar;9(3):e1003231 [PMID: 23555247]
  16. PLoS Pathog. 2009 Sep;5(9):e1000593 [PMID: 19779565]
  17. J Virol. 2013 Feb;87(3):1690-8 [PMID: 23175366]
  18. J Virol. 2014 Mar;88(6):3369-78 [PMID: 24390337]
  19. Curr Opin Oncol. 2003 Nov;15(6):431-9 [PMID: 14624225]
  20. PLoS One. 2012;7(3):e32947 [PMID: 22396801]
  21. J Virol. 2014 Sep 1;88(17):9830-41 [PMID: 24942571]
  22. Viral Immunol. 2014 Aug;27(6):267-76 [PMID: 24905060]
  23. J Immunol. 2011 Sep 1;187(5):2202-12 [PMID: 21810613]
  24. J Mol Biol. 2011 May 6;408(3):449-61 [PMID: 21396941]
  25. J Virol. 2014 Oct;88(19):11356-68 [PMID: 25056901]
  26. J Virol. 2010 Aug;84(16):8051-61 [PMID: 20519382]
  27. Immunity. 2011 May 27;34(5):637-50 [PMID: 21616434]
  28. Nat Med. 2009 Jul;15(7):798-801 [PMID: 19543282]
  29. J Immunol. 2005 Sep 1;175(5):2851-8 [PMID: 16116171]
  30. Nat Immunol. 2006 Feb;7(2):131-7 [PMID: 16424890]
  31. Cell Rep. 2012 Nov 29;2(5):1187-96 [PMID: 23142662]
  32. Nat Immunol. 2003 May;4(5):491-6 [PMID: 12692549]
  33. Virology. 2009 Sep 1;391(2):171-6 [PMID: 19628239]
  34. Virus Res. 1995 Dec;39(2-3):195-205 [PMID: 8837884]
  35. Virology. 2010 May 25;401(1):42-8 [PMID: 20206372]
  36. Genes Dev. 1990 Dec;4(12A):2112-20 [PMID: 1980119]
  37. Nature. 2006 Jan 12;439(7073):204-7 [PMID: 16306937]
  38. J Virol. 2005 Mar;79(5):2910-9 [PMID: 15709010]
  39. Adv Immunol. 2011;109:87-124 [PMID: 21569913]
  40. PLoS One. 2015;10(3):e0119173 [PMID: 25767882]
  41. Immunity. 2012 Apr 20;36(4):503-14 [PMID: 22520844]
  42. Nature. 2006 May 4;441(7089):101-5 [PMID: 16625202]
  43. J Gen Virol. 2004 Jun;85(Pt 6):1597-607 [PMID: 15166444]
  44. PLoS One. 2009;4(1):e4127 [PMID: 19122812]
  45. Oncogene. 1999 Nov 22;18(49):6853-66 [PMID: 10602461]
  46. Circulation. 2001 Feb 6;103(5):756-61 [PMID: 11156890]
  47. Nat Immunol. 2004 Jul;5(7):730-7 [PMID: 15208624]
  48. J Interferon Cytokine Res. 2006 Jun;26(6):373-9 [PMID: 16734557]
  49. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7944-9 [PMID: 21518880]
  50. Genes Immun. 2011 Sep;12(6):399-414 [PMID: 21490621]
  51. Science. 2006 Nov 10;314(5801):994-7 [PMID: 17038590]
  52. J Gen Virol. 2014 Dec;95(Pt 12):2649-57 [PMID: 25096816]
  53. J Exp Med. 2008 Jul 7;205(7):1601-10 [PMID: 18591409]
  54. Cell. 1996 Oct 4;87(1):13-20 [PMID: 8858144]
  55. Antiviral Res. 2013 Nov;100(2):337-45 [PMID: 24055449]
  56. Virology. 1998 Jun 5;245(2):229-40 [PMID: 9636362]
  57. J Virol. 2005 Apr;79(7):4460-9 [PMID: 15767446]
  58. J Virol. 2005 Jun;79(11):7269-72 [PMID: 15890966]
  59. Cell. 2006 Feb 24;124(4):783-801 [PMID: 16497588]
  60. Cell Mol Immunol. 2004 Oct;1(5):343-50 [PMID: 16285893]
  61. Nat Immunol. 2003 Jan;4(1):69-77 [PMID: 12483210]
  62. Nat Immunol. 2005 Nov;6(11):1087-95 [PMID: 16186825]
  63. Int Rev Immunol. 2011 Feb;30(1):16-34 [PMID: 21235323]
  64. J Biol Chem. 2007 Feb 9;282(6):3918-28 [PMID: 17158449]
  65. Respir Res. 2011;12:147 [PMID: 22054060]
  66. Acta Virol. 1994 Dec;38(6):345-60 [PMID: 7793359]
  67. J Virol. 2012 Apr;86(7):3767-76 [PMID: 22258259]
  68. Antimicrob Agents Chemother. 2007 Aug;51(8):2969-78 [PMID: 17548497]
  69. Infect Immun. 2005 May;73(5):3044-52 [PMID: 15845512]
  70. J Virol. 2007 Apr;81(8):3677-84 [PMID: 17267501]
  71. J Virol. 2006 May;80(9):4501-9 [PMID: 16611910]
  72. PLoS One. 2014;9(7):e102997 [PMID: 25047717]
  73. Hepatology. 2005 Sep;42(3):724-31 [PMID: 16116638]
  74. Curr Opin Pharmacol. 2009 Aug;9(4):514-20 [PMID: 19525145]
  75. J Virol. 2014 Oct;88(20):11658-70 [PMID: 25078697]
  76. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20446-51 [PMID: 19074283]
  77. J Gen Virol. 2002 Jun;83(Pt 6):1367-76 [PMID: 12029152]
  78. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7253-8 [PMID: 17438296]
  79. Curr Opin Immunol. 2007 Dec;19(6):615-22 [PMID: 17977705]
  80. J Virol. 2013 Jul;87(13):7348-56 [PMID: 23616646]
  81. J Virol. 2009 May;83(9):4412-22 [PMID: 19211759]
  82. J Immunol. 2011 Nov 15;187(10):5320-7 [PMID: 21998457]
  83. Antiviral Res. 2013 Feb;97(2):183-94 [PMID: 23261847]
  84. J Virol. 2013 Jul;87(13):7646-54 [PMID: 23637411]
  85. PLoS Pathog. 2010;6(11):e1001178 [PMID: 21079690]
  86. J Infect Dis. 2011 Jun 15;203(12):1784-90 [PMID: 21536800]
  87. Virology. 2005 Oct 10;341(1):72-9 [PMID: 16083932]
  88. Cell. 2005 Sep 9;122(5):669-82 [PMID: 16125763]
  89. Antiviral Res. 2007 Jan;73(1):1-11 [PMID: 16959331]
  90. Pediatr Infect Dis J. 2000 Aug;19(8):755-7 [PMID: 10959747]
  91. Oncogene. 2006 Oct 30;25(51):6844-67 [PMID: 17072332]
  92. J Virol. 2009 Nov;83(22):11581-7 [PMID: 19740998]
  93. J Virol. 2006 Jun;80(12):6072-83 [PMID: 16731946]
  94. J Biomed Sci. 2009;16:103 [PMID: 19925687]
  95. J Cell Sci. 2012 Oct 15;125(Pt 20):4761-9 [PMID: 22797917]
  96. PLoS One. 2013;8(5):e63431 [PMID: 23650567]
  97. Antivir Ther. 2011;16(1):51-8 [PMID: 21311108]
  98. Nat Rev Immunol. 2008 Jul;8(7):559-68 [PMID: 18575461]
  99. J Virol. 2012 Jan;86(1):185-94 [PMID: 22072781]
  100. Cell. 1988 Apr 8;53(1):37-43 [PMID: 3127059]
  101. Virol J. 2009;6:141 [PMID: 19751532]
  102. J Clin Virol. 2000 Jun;17(1):23-30 [PMID: 10814935]
  103. Blood. 2006 Aug 15;108(4):1284-90 [PMID: 16638933]
  104. Antiviral Res. 2013 Mar;97(3):264-9 [PMID: 23295352]
  105. Immunol Rev. 2009 Jan;227(1):75-86 [PMID: 19120477]
  106. J Virol. 2010 Jan;84(1):254-60 [PMID: 19846534]
  107. Curr Opin Immunol. 2008 Feb;20(1):17-22 [PMID: 18272355]
  108. J Infect Chemother. 2008 Apr;14(2):86-92 [PMID: 18622669]
  109. Nature. 2005 Oct 20;437(7062):1167-72 [PMID: 16177806]
  110. J Virol. 2011 Sep;85(17):8811-8 [PMID: 21697485]
  111. Virology. 2003 Mar 15;307(2):386-95 [PMID: 12667806]
  112. J Gen Virol. 2005 Dec;86(Pt 12):3263-9 [PMID: 16298971]
  113. PLoS Pathog. 2011 Mar;7(3):e1001311 [PMID: 21436888]
  114. Lab Invest. 2011 Sep;91(9):1337-50 [PMID: 21555996]
  115. Nat Commun. 2014;5:3344 [PMID: 24561744]

MeSH Term

Enterovirus A, Human
Hand, Foot and Mouth Disease
Host-Pathogen Interactions
Humans
Immune Evasion
Immunity, Innate
Journal Article Review
Article has an altmetric score of 6

Word Cloud

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