miRNA profiling in autism spectrum disorder in China.
Fengzhen Huang, Tieqiao Zhou, Xiaoxi Yao, Jiping Yi, Fei Zhou, Zhe Long, Xuan Hou, Chunrong Wang, Zhao Chen, Hong Jiang
Author Information
Fengzhen Huang: Department of Neurology & Institute of Translational Medicine at University of South China, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, PR China.
Tieqiao Zhou: Department of Laboratory Medicine & Institute of Translational Medicine at University of South China, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, PR China.
Xiaoxi Yao: Department of Neurology & Institute of Translational Medicine at University of South China, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, PR China.
Jiping Yi: Department of Neurology & Institute of Translational Medicine at University of South China, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, PR China.
Fei Zhou: Department of Neurology & Institute of Translational Medicine at University of South China, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, PR China.
Zhe Long: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.
Xuan Hou: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.
Chunrong Wang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.
Zhao Chen: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.
Hong Jiang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.
Autism spectrum disorder (ASD) is a clinically complex and heterogeneous disorder. It is characterized by impaired social abilities, disordered language, isolated areas of interest, and repetitive behaviors. Evidence suggested that the neuropathology of ASD is widely distributed, involving epigenetic regulation in the brain. MiRNAs are a group of endogenous non-coding RNAs that play a critical role in neurodevelopment, neuroplasticity, and other fundamental neurobiological processes. To study miRNA profiling in Autism spectrum disorder in China, we performed miRNA microarray followed quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Here, we describe detailed methods and analysis on these microarray data which has been deposited in Gene Expression Omnibus (GEO): GSE67979.
