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Nature reviews. Drug discovery
Apr, 2016;15 (4): 249-74.

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies.

Giovanni Musso, Maurizio Cassader, Roberto Gambino
Author Information
  1. Giovanni Musso: Gradenigo Hospital, Corso Regina Margherita 8, 10132 Turin, Italy.
  2. Maurizio Cassader: Department of Medical Sciences, University of Turin, Corso A.M. Dogliotti 14, 10126, Turin, Italy.
  3. Roberto Gambino: Department of Medical Sciences, University of Turin, Corso A.M. Dogliotti 14, 10126, Turin, Italy.
PMID: 26794269 DOI: 10.1038/nrd.2015.3

Abstract

Non-alcoholic fatty liver disease - the most common chronic liver disease - encompasses a histological spectrum ranging from simple steatosis to Non-alcoholic steatohepatitis (NASH). Over the next decade, NASH is projected to be the most common indication for liver transplantation. The absence of an effective pharmacological therapy for NASH is a major incentive for research into novel therapeutic approaches for this condition. The current focus areas for research include the modulation of nuclear transcription factors; agents that target lipotoxicity and oxidative stress; and the modulation of cellular energy homeostasis, metabolism and the inflammatory response. Strategies to enhance resolution of inflammation and fibrosis also show promise to reverse the advanced stages of liver disease.

References

  1. Pharmacogenet Genomics. 2010 Jan;20(1):1-8 [PMID: 19940802]
  2. Br J Pharmacol. 2015 Jun;172(12):3058-71 [PMID: 25659822]
  3. J Leukoc Biol. 2014 Dec;96(6):1087-100 [PMID: 25210146]
  4. J Biol Chem. 2006 May 26;281(21):14537-46 [PMID: 16492670]
  5. Int J Endocrinol. 2014;2014:751859 [PMID: 24872814]
  6. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):268-74 [PMID: 22178739]
  7. PLoS Med. 2014 Jul 22;11(7):e1001680 [PMID: 25050550]
  8. J Clin Invest. 2011 May;121(5):1858-70 [PMID: 21490391]
  9. FASEB J. 2014 Feb;28(2):836-48 [PMID: 24249635]
  10. Cancer Res. 2005 May 1;65(9):3535-7 [PMID: 15867344]
  11. Hepatology. 2010 Nov;52(5):1769-82 [PMID: 21038415]
  12. PLoS One. 2014 Nov 05;9(11):e112327 [PMID: 25372401]
  13. J Hepatol. 2006 Jun;44(6):1167-74 [PMID: 16618517]
  14. Arterioscler Thromb Vasc Biol. 2015 May;35(5):1080-91 [PMID: 25792450]
  15. Dig Liver Dis. 2015 Mar;47(3):226-32 [PMID: 25577300]
  16. Br J Nutr. 2012 Dec 28;108(12):2166-75 [PMID: 22414733]
  17. Cytokine Growth Factor Rev. 2015 Jun;26(3):311-27 [PMID: 25498524]
  18. J Immunol. 2010 Apr 1;184(7):3978-87 [PMID: 20207999]
  19. Biochim Biophys Acta. 2014 May;1843(5):902-14 [PMID: 24487063]
  20. Gastroenterology. 2008 Feb;134(2):556-67 [PMID: 18242221]
  21. PLoS One. 2013 Jun 18;8(6):e65763 [PMID: 23823755]
  22. Diabetes. 2008 May;57(5):1254-61 [PMID: 18268047]
  23. Hepatology. 2015 Aug;62(2):627-34 [PMID: 25626988]
  24. Oncotarget. 2014 Apr 30;5(8):2077-84 [PMID: 24809457]
  25. Hepatology. 2010 Mar;51(3):817-27 [PMID: 20112424]
  26. Circ Res. 2014 May 9;114(10):1576-84 [PMID: 24687132]
  27. Gastroenterology. 2014 Nov;147(5):1073-83.e6 [PMID: 25083607]
  28. Apoptosis. 2015 May;20(5):658-70 [PMID: 25682163]
  29. Hepatology. 2008 Nov;48(5):1632-43 [PMID: 18972444]
  30. Cell. 2003 Apr 18;113(2):159-70 [PMID: 12705865]
  31. Endocrinology. 2009 Dec;150(12):5384-94 [PMID: 19808779]
  32. Mol Cell Biol. 2013 May;33(10):2078-90 [PMID: 23508104]
  33. Diabetes. 2014 Dec;63(12):4064-75 [PMID: 25024372]
  34. Diabetes. 2012 Feb;61(2):346-54 [PMID: 22190646]
  35. Biochim Biophys Acta. 2014 Jul;1841(7):1012-20 [PMID: 24769340]
  36. Prog Lipid Res. 2013 Jan;52(1):175-91 [PMID: 23206728]
  37. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 1;307(7):G732-40 [PMID: 25104498]
  38. PLoS One. 2014 Jul 21;9(7):e103071 [PMID: 25048611]
  39. Biochem Biophys Res Commun. 2015 Mar 20;458(4):771-6 [PMID: 25681768]
  40. Nature. 2012 Feb 01;482(7384):179-85 [PMID: 22297845]
  41. Cell Metab. 2012 May 2;15(5):665-74 [PMID: 22560219]
  42. J Biol Chem. 1999 Nov 5;274(45):32048-54 [PMID: 10542237]
  43. Free Radic Biol Med. 2012 Feb 1;52(3):671-82 [PMID: 22155056]
  44. Gastroenterology. 2006 Jul;131(1):194-209 [PMID: 16831602]
  45. Circulation. 2015 Mar 24;131(12 ):1061-70 [PMID: 25613820]
  46. J Pathol. 2009 Jul;218(3):360-9 [PMID: 19334049]
  47. Hepatology. 2014 Jan;59(1):143-53 [PMID: 23832510]
  48. Hepatobiliary Surg Nutr. 2014 Dec;3(6):364-76 [PMID: 25568860]
  49. Gastroenterology. 2015 Mar;148(3):547-55 [PMID: 25461851]
  50. Hepatology. 2014 Feb;59(2):713-23 [PMID: 23929732]
  51. Diabetes. 2010 Apr;59(4):916-25 [PMID: 20103702]
  52. Eur J Pharmacol. 2015 Jan 5;746:56-62 [PMID: 25445048]
  53. Int J Pharm. 2015 Jul 25;490(1-2):55-64 [PMID: 25987211]
  54. Arch Toxicol. 2015 Nov;89(11):2089-103 [PMID: 25182422]
  55. J Clin Endocrinol Metab. 2011 Sep;96(9):2889-97 [PMID: 21752880]
  56. Cardiovasc Res. 2013 Dec 1;100(3):450-60 [PMID: 24068000]
  57. Biochem Biophys Res Commun. 2004 Nov 12;324(2):697-704 [PMID: 15474484]
  58. Biomed Res Int. 2015;2015:597134 [PMID: 26120584]
  59. Hepatology. 2013 Feb;57(2):577-89 [PMID: 22987396]
  60. Biochim Biophys Acta. 2015 Jun;1852(6):1071-113 [PMID: 25652123]
  61. Cell Metab. 2013 Sep 3;18(3):333-40 [PMID: 24011069]
  62. Diabetologia. 2014 Nov;57(11):2393-404 [PMID: 25120095]
  63. Biochem J. 2005 May 1;387(Pt 3):601-8 [PMID: 15595924]
  64. Nature. 2010 Dec 23;468(7327):1100-4 [PMID: 21179166]
  65. Cell Mol Gastroenterol Hepatol. 2015 Jan;1(1):17-27 [PMID: 25729762]
  66. Hepatology. 2014 Aug;60(2):531-44 [PMID: 24668763]
  67. Biochem J. 1997 Mar 1;322 ( Pt 2):567-73 [PMID: 9065778]
  68. Gastroenterology. 2003 Aug;125(2):544-55 [PMID: 12891557]
  69. Cancer Res. 2005 Sep 1;65(17):7546-53 [PMID: 16140916]
  70. Front Physiol. 2014 Sep 02;5:331 [PMID: 25228885]
  71. J Mol Med (Berl). 2014 Oct;92 (10 ):1069-82 [PMID: 24861026]
  72. Mol Pharmacol. 2015 Apr;87(4):674-82 [PMID: 25628225]
  73. Food Chem Toxicol. 2014 Jan;63:166-73 [PMID: 23978414]
  74. Cell Metab. 2011 Nov 2;14 (5):612-22 [PMID: 22055504]
  75. Nat Med. 2010 Sep;16(9):1009-17 [PMID: 20818376]
  76. Diabetes. 2010 Nov;59(11):2781-9 [PMID: 20682689]
  77. Drug Discov Today. 2015 May;20(5):618-28 [PMID: 25463033]
  78. Biochim Biophys Acta. 2014 Oct;1840(10 ):3153-61 [PMID: 25065288]
  79. PLoS One. 2013 Oct 09;8(10):e75361 [PMID: 24130706]
  80. J Lipid Res. 2014 Jul;55(7):1254-66 [PMID: 24864274]
  81. Lipids Health Dis. 2013 Nov 04;12:165 [PMID: 24188280]
  82. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6506-11 [PMID: 23533277]
  83. Cancer Lett. 2015 Apr 28;360(1):17-27 [PMID: 25661734]
  84. Endocrinology. 2013 Jan;154(1):65-76 [PMID: 23183172]
  85. Pharm Res. 2013 Sep;30(9):2199-208 [PMID: 23896737]
  86. Mol Cell Biol. 2008 Jan;28(1):188-200 [PMID: 17954559]
  87. Biochem Biophys Res Commun. 2011 Aug 26;412(2):197-202 [PMID: 21806970]
  88. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2839-46 [PMID: 23023374]
  89. Immunol Cell Biol. 2015 Apr;93(4):372-83 [PMID: 25708536]
  90. Blood. 2003 Jan 15;101(2):545-51 [PMID: 12393563]
  91. Hepatology. 2012 Feb;55(2):419-28 [PMID: 22006541]
  92. Sci Transl Med. 2012 Nov 28;4(162):162ra153 [PMID: 23197570]
  93. Mol Cell. 2008 Apr 25;30(2):214-26 [PMID: 18439900]
  94. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5748-52 [PMID: 21436037]
  95. PLoS One. 2013 Jul 22;8(7):e70599 [PMID: 23894677]
  96. J Biol Chem. 2013 Jan 18;288(3):1726-38 [PMID: 23168409]
  97. Hepatology. 2014 Mar;59(3):1060-72 [PMID: 24481979]
  98. Diabetes. 2008 May;57(5):1355-62 [PMID: 18316359]
  99. Biochem J. 2015 Jul 1;469(1):71-82 [PMID: 25915851]
  100. Autophagy. 2015;11(2):271-84 [PMID: 25650776]
  101. Genes Dev. 2004 Jan 15;18(2):157-69 [PMID: 14729567]
  102. Br J Nutr. 2012 Jan;107(2):202-10 [PMID: 21733326]
  103. Endocrine. 2015 Aug;49(3):683-92 [PMID: 25557015]
  104. Expert Opin Pharmacother. 2015 Mar;16(4):597-606 [PMID: 25674933]
  105. Cell Cycle. 2012 Mar 1;11(5):922-33 [PMID: 22333591]
  106. Nat Med. 2011 Feb;17 (2):179-88 [PMID: 21217695]
  107. Mol Med Rep. 2015 May;11(5):3647-51 [PMID: 25544258]
  108. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7432-7 [PMID: 17452648]
  109. J Clin Invest. 2014 Aug;124(8):3566-78 [PMID: 24983318]
  110. Nucleic Acids Res. 2014 Jan;42(2):882-92 [PMID: 24165878]
  111. Hepatology. 2012 Jun;55(6):1727-37 [PMID: 22183976]
  112. Annu Rev Med. 2010;61:375-92 [PMID: 20059344]
  113. J Clin Invest. 2006 Apr;116(4):1102-9 [PMID: 16557297]
  114. Lab Invest. 2010 Feb;90(2):257-65 [PMID: 19997066]
  115. Endocrinology. 2015 Jul;156(7):2470-81 [PMID: 25924103]
  116. Aging (Albany NY). 2010 Sep;2(9):627-31 [PMID: 20930261]
  117. PPAR Res. 2013;2013:938401 [PMID: 23476633]
  118. Acta Pharmacol Sin. 2015 Apr;36(4):483-96 [PMID: 25832429]
  119. Biochem Biophys Res Commun. 2006 Nov 17;350(2):385-91 [PMID: 17010940]
  120. Biochim Biophys Acta. 2015 Apr;1851(4):331-9 [PMID: 25152163]
  121. Cell Metab. 2011 Mar 2;13(3):241-7 [PMID: 21356514]
  122. FASEB J. 2003 Sep;17(12):1745-7 [PMID: 12958196]
  123. Oxid Med Cell Longev. 2014;2014:169216 [PMID: 24987492]
  124. J Hepatol. 2014 May;60(5):1017-25 [PMID: 24362075]
  125. Hepatology. 2015 Jul;62(1):135-46 [PMID: 25808625]
  126. Toxicol Appl Pharmacol. 2014 Oct 15;280(2):207-15 [PMID: 25123789]
  127. Biochem Biophys Res Commun. 2011 Mar 18;406(3):371-6 [PMID: 21329659]
  128. J Hepatol. 2014 Nov;61(5):1126-34 [PMID: 24946279]
  129. Hepatology. 2015 Jun;61(6):2104-6 [PMID: 25753820]
  130. BMC Immunol. 2014 Sep 26;15:37 [PMID: 25257976]
  131. J Biol Chem. 2012 Aug 24;287(35):29579-88 [PMID: 22773877]
  132. J Lipid Res. 2011 Apr;52(4):657-67 [PMID: 21317108]
  133. Diabetes. 2010 Jun;59(6):1397-406 [PMID: 20332342]
  134. J Hepatol. 2015 Jun;62(6):1412-9 [PMID: 25623823]
  135. Liver Int. 2014 Oct;34(9):1402-13 [PMID: 24650018]
  136. Mol Pharm. 2009 Jan-Feb;6(1):182-9 [PMID: 19183106]
  137. Curr Top Med Chem. 2014;14(19):2129-42 [PMID: 25388537]
  138. Pharmacol Ther. 2015 Apr;148:47-65 [PMID: 25460034]
  139. Hepatology. 2007 Oct;46(4):1081-90 [PMID: 17654743]
  140. Org Biomol Chem. 2013 Feb 7;11(5):849-58 [PMID: 23242135]
  141. Diabetologia. 2011 Apr;54(4):922-34 [PMID: 21161163]
  142. J Pharmacol Exp Ther. 2009 Jan;328(1):116-22 [PMID: 18948497]
  143. PLoS One. 2013 Dec 02;8(12):e82608 [PMID: 24312665]
  144. J Hepatol. 2011 May;54(5):975-83 [PMID: 21145823]
  145. Pharmacol Res. 2015 Jan;91:104-14 [PMID: 25447793]
  146. J Clin Invest. 2015 Jan;125(1):25-32 [PMID: 25654547]
  147. Am J Pathol. 2010 Sep;177(3):1214-24 [PMID: 20651240]
  148. Hepatology. 2014 Feb;59(2):630-42 [PMID: 23959575]
  149. J Antimicrob Chemother. 2014 Jul;69(7):1903-10 [PMID: 24651825]
  150. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9232-7 [PMID: 21576456]
  151. PLoS One. 2015 May 20;10(5):e0126910 [PMID: 25993337]
  152. J Clin Invest. 2004 May;113(10):1408-18 [PMID: 15146238]
  153. J Leukoc Biol. 2012 Aug;92(2):249-58 [PMID: 22493082]
  154. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6737-42 [PMID: 8692888]
  155. Lab Invest. 2013 Feb;93(2):218-29 [PMID: 23207450]
  156. Int J Obes (Lond). 2014 Mar;38(3):470-3 [PMID: 23958793]
  157. Hepatology. 2014 Mar;59(3):898-910 [PMID: 23813842]
  158. Molecules. 2014 Oct 24;19(11):17154-72 [PMID: 25347459]
  159. Pharm Res. 2014 May;31(5):1158-69 [PMID: 24249038]
  160. Mol Med. 2015 May 22;21:453-65 [PMID: 26018806]
  161. J Inflamm Res. 2015 Jan 16;8:15-27 [PMID: 25653548]
  162. Clin Biochem. 2015 Sep;48(13-14):923-30 [PMID: 26151226]
  163. Hepatology. 2013 Jun;57(6):2189-201 [PMID: 23339067]
  164. J Biol Chem. 2014 Oct 24;289(43):29751-65 [PMID: 25170079]
  165. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9448-53 [PMID: 22566629]
  166. J Pharmacol Exp Ther. 2005 Aug;314(2):584-95 [PMID: 15860571]
  167. Nat Med. 2011 Jan;17(1):55-63 [PMID: 21186369]
  168. J Pharmacol Exp Ther. 2014 Jul;350(1):56-68 [PMID: 24784847]
  169. Diabetes. 2009 Jan;58(1):250-9 [PMID: 18840786]
  170. J Immunol. 2012 Sep 1;189(5):2597-605 [PMID: 22844113]
  171. FASEB J. 2013 Jan;27(1):368-78 [PMID: 23038751]
  172. Life Sci. 2014 Mar 7;98(1):24-30 [PMID: 24412384]
  173. Hepatology. 2014 Nov;60(5):1593-606 [PMID: 24995693]
  174. Liver Int. 2014 Aug;34(7):1074-83 [PMID: 24106929]
  175. Acta Histochem Cytochem. 2014;47(5):185-94 [PMID: 25861124]
  176. Sem Hop. 1975 Jul 10-20;51(31-34):2095-102 [PMID: 170685]
  177. J Biol Chem. 2003 May 23;278(21):18938-44 [PMID: 12646584]
  178. J Med Chem. 2002 Aug 15;45(17 ):3569-72 [PMID: 12166927]
  179. Mol Cell Biol. 2014 Sep;34(17):3305-20 [PMID: 24958099]
  180. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1;302(11):G1310-21 [PMID: 22442158]
  181. Nutr Res. 2014 Oct;34(10):837-43 [PMID: 25311610]
  182. J Inflamm (Lond). 2012 Nov 28;9(1):49 [PMID: 23192004]
  183. J Clin Invest. 2009 Jul;119(7):1858-70 [PMID: 19603542]
  184. Hepatology. 2015 Jul;62(1):312-4 [PMID: 25904459]
  185. Hepatology. 2006 Jul;44(1):27-33 [PMID: 16799979]
  186. Biochim Biophys Acta. 2014 Sep;1842(9):1844-54 [PMID: 25016145]
  187. Food Chem Toxicol. 2013 Feb;52:53-60 [PMID: 23123425]
  188. Hepatology. 2009 Jun;49(6):2068-79 [PMID: 19437491]
  189. J Nutr. 2012 Jun;142(6):1026-32 [PMID: 22535755]
  190. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5060-5 [PMID: 16549783]
  191. PLoS One. 2011;6(8):e22775 [PMID: 21857953]
  192. J Mol Cell Cardiol. 2015 Jul;84:24-35 [PMID: 25870158]
  193. Prog Lipid Res. 2014 Apr;54:53-67 [PMID: 24513486]
  194. Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E421-34 [PMID: 16985262]
  195. Hepatology. 2013 Jul;58(1):337-50 [PMID: 23460364]
  196. Hepatology. 2014 Apr;59(4):1577-90 [PMID: 24677197]
  197. Nutr Metab (Lond). 2014 Aug 12;11:35 [PMID: 25140191]
  198. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8 [PMID: 20616029]
  199. Carcinogenesis. 2013 Jul;34(7):1458-67 [PMID: 23455382]
  200. Eur J Pharmacol. 2009 Nov 10;622(1-3):45-51 [PMID: 19766624]
  201. J Biol Chem. 2013 May 17;288(20):14569-83 [PMID: 23543742]
  202. PLoS One. 2013;8(2):e57915 [PMID: 23451284]
  203. Diabetes. 2010 Feb;59(2):347-57 [PMID: 19934001]
  204. Int J Biochem Cell Biol. 2015 Apr;61:8-19 [PMID: 25622557]
  205. Hepatology. 2009 Jul;50(1):261-74 [PMID: 19554540]
  206. Lancet. 2015 Mar 14;385(9972):956-65 [PMID: 25468160]
  207. Diabetologia. 2012 Apr;55(4):885-904 [PMID: 22278337]
  208. PLoS One. 2014 Jun 04;9(6):e98896 [PMID: 24896564]
  209. J Thorac Dis. 2014 Nov;6(11):1548-56 [PMID: 25478196]
  210. Cell. 2007 Apr 6;129(1):123-34 [PMID: 17418791]
  211. Nucleic Acids Res. 2001 Sep 1;29(17 ):3595-602 [PMID: 11522829]
  212. Eur J Pharmacol. 2006 Apr 24;536(1-2):182-91 [PMID: 16574099]
  213. Gut. 2015 Feb;64(2):312-21 [PMID: 24837171]
  214. J Biol Chem. 2004 Aug 13;279(33):34922-30 [PMID: 15205467]
  215. Handb Exp Pharmacol. 2013;(215):169-86 [PMID: 23579455]
  216. World J Hepatol. 2015 May 18;7(8):1012-9 [PMID: 26052390]
  217. World J Gastroenterol. 2014 Nov 14;20(42):15727-35 [PMID: 25400456]
  218. J Immunol. 2013 Jun 15;190(12):6478-87 [PMID: 23686496]
  219. Nutrition. 2014 Jul-Aug;30(7-8):915-9 [PMID: 24985011]
  220. Hepatology. 2015 Feb;61(2):486-96 [PMID: 25203315]
  221. Pharmacol Res. 2012 Sep;66(3):260-8 [PMID: 22627169]
  222. Cancer Res. 2003 Dec 1;63(23):8302-11 [PMID: 14678989]
  223. Drug Metab Dispos. 2010 Dec;38(12):2293-301 [PMID: 20805291]
  224. Diabetes. 2013 Jun;62(6):1932-44 [PMID: 23349493]
  225. PLoS One. 2013;8(2):e55979 [PMID: 23441159]
  226. Hepatology. 2014 Nov;60(5):1581-92 [PMID: 25043405]
  227. Eur J Immunol. 2015 Feb;45(2):531-43 [PMID: 25359399]
  228. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2092-103.e1-6 [PMID: 24582567]
  229. J Immunol. 2013 May 15;190(10):5226-36 [PMID: 23596313]
  230. Hepatology. 2014 Jan;59(1):154-69 [PMID: 23832448]
  231. Endocrinology. 2014 Mar;155(3):769-82 [PMID: 24424044]
  232. Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):831-6 [PMID: 19359660]
  233. PLoS One. 2013 Dec 18;8(12):e83481 [PMID: 24367597]
  234. PLoS One. 2012;7(5):e38438 [PMID: 22675463]
  235. J Lipid Res. 2014 Mar;55(3):363-74 [PMID: 24465016]
  236. J Lipid Res. 2015 Feb;56(2):277-85 [PMID: 25520429]
  237. Hepatology. 2010 Jul;52(1):278-90 [PMID: 20578145]
  238. Bioorg Chem. 2014 Dec;57:231-41 [PMID: 25146937]
  239. J Clin Invest. 2013 Jan;123(1):443-54 [PMID: 23241962]
  240. Cell Death Dis. 2014 Apr 17;5:e1179 [PMID: 24743734]
  241. PLoS One. 2013;8(2):e56100 [PMID: 23409132]
  242. PLoS One. 2013;8(1):e51588 [PMID: 23359794]
  243. World J Gastroenterol. 2014 Mar 14;20(10):2515-32 [PMID: 24627588]
  244. J Biol Chem. 2007 Aug 3;282(31):22678-88 [PMID: 17526931]
  245. J Biol Chem. 2013 Oct 18;288(42):30000-8 [PMID: 24014025]
  246. J Biol Chem. 2012 Nov 23;287(48):40161-72 [PMID: 23066023]
  247. PLoS One. 2011 Feb 16;6(2):e16957 [PMID: 21359215]
  248. Mol Pharmacol. 2013 Jul;84(1):62-70 [PMID: 23592516]
  249. Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G320-7 [PMID: 24356885]
  250. Diabetes. 2013 Apr;62(4):1109-20 [PMID: 23274901]
  251. J Clin Invest. 2010 Nov;120(11):4129-40 [PMID: 20978355]
  252. Mol Pharmacol. 2015 Feb;87(2):174-82 [PMID: 25395043]
  253. Metabolism. 2015 Sep;64(9):982-90 [PMID: 26024755]
  254. Drug Metab Dispos. 2015 Mar;43(3):335-43 [PMID: 25527709]
  255. Endocrinology. 2008 Jun;149(6):3215-23 [PMID: 18325987]
  256. Nature. 2007 Jun 28;447(7148):1116-20 [PMID: 17515919]
  257. Eur Rev Med Pharmacol Sci. 2014;18(18):2736-41 [PMID: 25317811]
  258. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5 [PMID: 20080636]
  259. Mol Cell Endocrinol. 2014 Jun 25;391(1-2):30-40 [PMID: 24784707]
  260. Cell Metab. 2014 Jul 1;20(1):133-44 [PMID: 24910242]
  261. Endocrinology. 2013 Mar;154(3):1069-79 [PMID: 23372021]
  262. Gastroenterology. 2014 Feb;146(2):539-49.e7 [PMID: 24184811]
  263. Hepatology. 2004 May;39(5):1286-96 [PMID: 15122757]
  264. J Transl Med. 2015 Jan 27;13:24 [PMID: 25623289]
  265. Mediators Inflamm. 2015;2015:272313 [PMID: 25653476]
  266. PLoS One. 2014 Nov 03;9(11):e111767 [PMID: 25365322]
  267. J Nutr Biochem. 2014 Feb;25(2):151-6 [PMID: 24445039]
  268. J Nutr Biochem. 2015 Mar;26(3):201-10 [PMID: 25468612]
  269. Cell Biosci. 2014 Nov 25;4:71 [PMID: 25937892]
  270. Hepatology. 2010 Jun;51(6):1998-2007 [PMID: 20512988]
  271. Liver Int. 2015 Mar;35(3):953-66 [PMID: 24750664]
  272. Cell Signal. 2014 Jan;26(1):141-8 [PMID: 24100264]
  273. PLoS One. 2012;7(11):e49345 [PMID: 23209571]
  274. Expert Opin Investig Drugs. 2014 Dec;23(12):1703-11 [PMID: 25251405]
  275. Cell. 2011 Aug 5;146(3):408-20 [PMID: 21816276]
  276. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G605-14 [PMID: 23328207]
  277. Hepatology. 2013 Dec;58(6):1941-52 [PMID: 23703580]
  278. ChemMedChem. 2014 Apr;9(4):699-705 [PMID: 24504667]
  279. PLoS One. 2011;6(9):e23943 [PMID: 21912653]
  280. Biol Pharm Bull. 2014;37(10):1655-60 [PMID: 25099343]
  281. Glycobiology. 2015 Feb;25(2):136-50 [PMID: 25303959]
  282. Food Chem Toxicol. 2014 Feb;64:94-103 [PMID: 24275089]
  283. Hepatology. 2015 Jan;61(1):98-107 [PMID: 24849310]
  284. Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L904-11 [PMID: 25770181]
  285. Diabetes. 2013 Apr;62(4):1186-95 [PMID: 23193181]
  286. Hepatology. 2012 Jun;55(6):2005-23 [PMID: 22488764]

MeSH Term

Autophagy
Energy Metabolism
Humans
Immunity, Cellular
Inflammation
Lipotropic Agents
Liver
Liver Cirrhosis
Medication Therapy Management
Non-alcoholic Fatty Liver Disease
Oxidative Stress
Transcription Factors

Chemicals

Lipotropic Agents
Transcription Factors
Journal Article Review
Article has an altmetric score of 40

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Created with Highcharts 10.0.0liverdiseaseNASHNon-alcoholic-commonresearchtherapeuticmodulationfattychronicencompasseshistologicalspectrumrangingsimplesteatosisnon-alcoholicsteatohepatitisnextdecadeprojectedindicationtransplantationabsenceeffectivepharmacologicaltherapymajorincentivenovelapproachesconditioncurrentfocusareasincludenucleartranscriptionfactorsagentstargetlipotoxicityoxidativestresscellularenergyhomeostasismetabolisminflammatoryresponseStrategiesenhanceresolutioninflammationfibrosisalsoshowpromisereverseadvancedstagessteatohepatitis:emergingmoleculartargetsstrategies

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