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Autophagy
05 03, 2016;12 (5): 900-4.

Emerging nexus between RAB GTPases, autophagy and neurodegeneration.

Navodita Jain, Subramaniam Ganesh
Author Information
  1. Navodita Jain: a Department of Biological Sciences & Bioengineering , Indian Institute of Technology , Kanpur , India.
  2. Subramaniam Ganesh: a Department of Biological Sciences & Bioengineering , Indian Institute of Technology , Kanpur , India.
PMID: 26985808 DOI: 10.1080/15548627.2016.1147673

Abstract

The RAB class of small GTPases includes the major regulators of intracellular communication, which are involved in vesicle generation through fusion and fission, and vesicular trafficking. RAB proteins also play an imperative role in neuronal maintenance and survival. Recent studies in the field of neurodegeneration have also highlighted the process of autophagy as being essential for neuronal maintenance. Here we review the emerging roles of RAB proteins in regulating macroautophagy and its impact in the context of neurodegenerative diseases.

Keywords

GTPase RAB proteins autophagy endocytosis intracellular trafficking neurodegeneration neuronal maintenance stress response

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MeSH Term

Animals
Autophagy
Biological Transport
Humans
Neurodegenerative Diseases
Neurons
Protein Transport
rab GTP-Binding Proteins

Chemicals

rab GTP-Binding Proteins
Journal Article Review Research Support, Non-U.S. Gov't
Article has an altmetric score of 2

Word Cloud

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