A prospective, multicentre study on the use of epidermal grafts to optimise outpatient wound management.

Nadine Hachach-Haram, Nicola Bystrzonowski, Muholan Kanapathy, Oliver Smith, Keith Harding, Ash Mosahebi, Toby Richards
Author Information
  1. Nadine Hachach-Haram: Royal Free Hospital Wound Healing Group, Department of Plastic and Reconstructive Surgery, The Royal Free Hospital, London, UK.
  2. Nicola Bystrzonowski: Royal Free Hospital Wound Healing Group, Department of Plastic and Reconstructive Surgery, The Royal Free Hospital, London, UK.
  3. Muholan Kanapathy: Royal Free Hospital Wound Healing Group, Department of Plastic and Reconstructive Surgery, The Royal Free Hospital, London, UK.
  4. Oliver Smith: Royal Free Hospital Wound Healing Group, Department of Plastic and Reconstructive Surgery, The Royal Free Hospital, London, UK.
  5. Keith Harding: Wound Healing Research Unit, School of Medicine, Cardiff University, Cardiff, UK.
  6. Ash Mosahebi: Royal Free Hospital Wound Healing Group, Department of Plastic and Reconstructive Surgery, The Royal Free Hospital, London, UK.
  7. Toby Richards: Royal Free Hospital Wound Healing Group, Department of Plastic and Reconstructive Surgery, The Royal Free Hospital, London, UK.

Abstract

Current wound management through the use of a split-thickness skin graft often requires hospital admission, a period of immobility, attentive donor site wound care and pain management. This study evaluates the feasibility of using a novel epidermal graft-harvesting device (CelluTome) that allows pain-free epidermal skin grafting in the outpatient clinic setting. A prospective series of 35 patients was performed in 2 centres, involving 10 acute and 25 chronic wounds. All patients were subjected to epidermal grafting in the outpatient specialist clinic, without the use of anaesthesia, and allowed to return home after the procedure. Completely healed wounds were noted in 22 patients (62·9%). The overall mean time for 50% and 100% reduction in wound size was 3·31 ± 2·33 and 5·91 ± 3·48 weeks, respectively. There was no significant difference in healing times between the acute and chronic wounds (50% reduction in wound size; acute 2·20 ± 0·91 weeks versus chronic 3·73 ± 2·63 weeks, P = 0·171. Hundred percent reduction in wound size; acute 4·80 ± 1·61 weeks versus chronic 6·83 ± 4·47 weeks, P = 0·183). The mean time for donor site healing was 5·49 ± 1·48 days. The mean pain score during graft harvest was 1·42 ± 0·95, and the donor site Vancouver Scar Scale was 0 for all cases at 6 weeks. This automated device offers autologous skin harvesting in the outpatient setting with minimal or no pain and a scar free donor site, equally benefiting both the acute and chronic wounds. It has the potential to save NHS resources by eliminating the need for theatre space and a hospital bed while at the same time benefiting patient care.

Keywords

References

  1. Burns. 2010 Nov;36(7):999-1005 [PMID: 20381967]
  2. Arch Dermatol. 1971 Dec;104(6):592-600 [PMID: 4943479]
  3. Plast Reconstr Surg. 2009 Jul;124(1):298-306 [PMID: 19568092]
  4. J Eur Acad Dermatol Venereol. 2008 Jan;22(1):7-10 [PMID: 18181967]
  5. Int J Dermatol. 2014 Aug;53(8):e384-6 [PMID: 24738744]
  6. Protoplasma. 2004 Jun;223(2-4):67-78 [PMID: 15221512]
  7. Lancet. 1964 Jun 27;2(7348):1444-5 [PMID: 14149183]
  8. Virchows Arch A Pathol Anat Histol. 1981;392(2):217-30 [PMID: 6169192]
  9. Adv Skin Wound Care. 2014 Jan;27(1):20-5 [PMID: 24343389]
  10. Int Rev Cytol. 1981;69:271-318 [PMID: 6163744]
  11. Nurs Times. 2008 Jan 22-28;104(3):44-5 [PMID: 18293879]
  12. Int Wound J. 2016 Dec;13(6):1193-1197 [PMID: 25818405]
  13. Cell. 1987 Sep 25;50(7):1131-7 [PMID: 3497724]
  14. Plast Reconstr Surg. 2006 Sep 15;118(4):909-918 [PMID: 16980850]

MeSH Term

Adolescent
Adult
Aged
Aged, 80 and over
Ambulatory Care
Epidermis
Female
Humans
Male
Middle Aged
Prospective Studies
Skin Transplantation
Treatment Outcome
United Kingdom
Wound Healing
Wounds and Injuries
Young Adult

Word Cloud

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