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Immunology
07, 2016;148 (3): 287-303.

Functional annotation of the T-cell immunoglobulin mucin family in birds.

Tuanjun Hu, Zhiguang Wu, Lonneke Vervelde, Lisa Rothwell, David A Hume, Pete Kaiser
Author Information
  1. Tuanjun Hu: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
  2. Zhiguang Wu: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
  3. Lonneke Vervelde: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
  4. Lisa Rothwell: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
  5. David A Hume: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
  6. Pete Kaiser: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
PMID: 26997606 DOI: 10.1111/imm.12607

Abstract

T-cell immunoglobulin and mucin (TIM) family molecules are cell membrane proteins, preferentially expressed on various immune cells and implicated in recognition and clearance of apoptotic cells. Little is known of their function outside human and mouse, and nothing outside mammals. We identified only two TIM genes (chTIM) in the chicken genome, putative orthologues of mammalian TIM1 and TIM4, and cloned the respective cDNAs. Like mammalian TIM1, chTIM1 expression was restricted to lymphoid tissues and immune cells. The gene chTIM4 encodes at least five splice variants with distinct expression profiles that also varied between strains of chicken. Expression of chTIM4 was detected in myeloid antigen-presenting cells, and in γδ T cells, whereas mammalian TIM4 is not expressed in T cells. Like the mammalian proteins, chTIM1 and chTIM4 fusion proteins bind to phosphatidylserine, and are thereby implicated in recognition of apoptotic cells. The chTIM4-immunoglobulin fusion protein also had co-stimulatory activity on chicken T cells, suggesting a function in antigen presentation.

Keywords

TIM1 TIM4 chicken comparative immunology

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Grants

  1. BB/M011925/1/Biotechnology and Biological Sciences Research Council
  2. BBS/E/D/20320000/Biotechnology and Biological Sciences Research Council
  3. BB/H012559/1/Biotechnology and Biological Sciences Research Council

MeSH Term

Animals
Apoptosis
Avian Proteins
Cells, Cultured
Chickens
Cloning, Molecular
Computational Biology
Hepatitis A Virus Cellular Receptor 1
Humans
Lymphoid Tissue
Membrane Proteins
Mice
Polymorphism, Genetic
Protein Binding
Sequence Analysis, DNA
Signal Transduction
T-Lymphocytes

Chemicals

Avian Proteins
HAVCR1 protein, human
Hepatitis A Virus Cellular Receptor 1
Membrane Proteins
TIMD4 protein, human
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 3

Word Cloud

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