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Oncotarget
May 03, 2016;7 (18): 26016-26.

miR-340 and ZEB1 negative feedback loop regulates TGF-β- mediated breast cancer progression.

Li-Kun Hou, Yue Yu, Ye-Gong Xie, Jie Wang, Jie-Fei Mao, Bin Zhang, Xin Wang, Xu-Chen Cao
Author Information
  1. Li-Kun Hou: The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
  2. Yue Yu: The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
  3. Ye-Gong Xie: The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
  4. Jie Wang: The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
  5. Jie-Fei Mao: The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
  6. Bin Zhang: The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
  7. Xin Wang: The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
  8. Xu-Chen Cao: The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
PMID: 27036021 DOI: 10.18632/oncotarget.8421

Abstract

MicroRNAs act as key regulators in carcinogenesis and progression in various cancers. In present study, we explored the role of miR-340 in the breast cancer progression. Our results showed that overexpression of miR-340 inhibits breast cancer cell proliferation and invasion, whereas depletion of miR-340 promotes breast cancer progression. Molecularly, ZEB1 was identified as a target gene of miR-340 and miR-340 suppressed the expression of ZEB1 by directly binding to the 3'-UTR of ZEB1. Furthermore, ZEB1 transcriptionally suppresses miR-340 expression. The negative feedback loop regulated TGF-β-mediated breast cancer progression. In conclusion, our data suggested that miR-340 acted as a tumor suppressor in breast cancer progression.

Keywords

EMT TGF-β ZEB1 breast cancer miR-340

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MeSH Term

Apoptosis
Biomarkers, Tumor
Breast Neoplasms
Cell Adhesion
Cell Movement
Cell Proliferation
Disease Progression
Epithelial-Mesenchymal Transition
Feedback, Physiological
Female
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs
Transforming Growth Factor beta
Tumor Cells, Cultured
Zinc Finger E-box-Binding Homeobox 1

Chemicals

Biomarkers, Tumor
MIRN340 microRNA, human
MicroRNAs
Transforming Growth Factor beta
ZEB1 protein, human
Zinc Finger E-box-Binding Homeobox 1
Journal Article
Article has an altmetric score of 1

Word Cloud

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