Walk like me, talk like me. The connection between mirror neurons and autism spectrum disorder.

Jillian M Saffin, Hassaan Tohid
Author Information
  1. Jillian M Saffin: Department of Psychology, Northern Arizona University, Arizona, United States of America.

Abstract

Understanding social cognition has become a hallmark in deciphering autism spectrum disorder. Neurobiological theories are taking precedence in causation studies as researchers look to abnormalities in brain development as the cause of deficits in social behavior, cognitive processes, and language. Following their discovery in the 1990s, mirror neurons have become a dominant theory for that the mirror neuron system may play a critical role in the pathophysiology of various symptoms of autism. Over the decades, the theory has evolved from the suggestion of a broken mirror neuron system to impairments in mirror neuron circuitry. The mirror neuron system has not gained total support due to inconsistent findings; a comprehensive analysis of the growing body of research could shed light on the benefits, or the disadvantage of continuing to study mirror neurons and their connection to autism.

References

  1. Behav Brain Res. 2011 Oct 1;223(2):342-7 [PMID: 21575660]
  2. Nat Neurosci. 2008 Nov;11(11):1267-9 [PMID: 18820694]
  3. J Child Psychol Psychiatry. 2010 Sep;51(9):981-8 [PMID: 20524939]
  4. Rev Neurol. 2013 Feb 22;56 Suppl 1:S35-43 [PMID: 23446723]
  5. J Pediatr. 2013 Jul;163(1):73-8 [PMID: 23410601]
  6. Hum Brain Mapp. 2011 Jul;32(7):1013-28 [PMID: 20645311]
  7. Exp Brain Res. 1992;91(1):176-80 [PMID: 1301372]
  8. Dev Cogn Neurosci. 2011 Apr;1(2):110-23 [PMID: 21528008]
  9. Cereb Cortex. 2015 Aug;25(8):2076-82 [PMID: 24532320]
  10. Rev Neurol. 2011 Mar 1;52 Suppl 1:S141-6 [PMID: 21365596]
  11. Biol Psychiatry. 2011 May 1;69(9):832-8 [PMID: 21310395]
  12. Curr Biol. 2013 Dec 2;23(23):R1057-62 [PMID: 24309286]
  13. Rev Neurol (Paris). 2013 Apr;169(4):285-90 [PMID: 23395409]
  14. Neurosci Biobehav Rev. 2012 Jan;36(1):341-9 [PMID: 21782846]
  15. Brain Nerve. 2014 Jun;66(6):647-53 [PMID: 24899346]
  16. Curr Opin Psychiatry. 2008 May;21(3):281-5 [PMID: 18382228]
  17. J Neurosci Res. 2009 Aug 1;87(10):2245-54 [PMID: 19301429]
  18. Brain Nerve. 2014 Jun;66(6):635-46 [PMID: 24899345]
  19. PLoS One. 2014 Mar 24;9(3):e92002 [PMID: 24663967]
  20. Soc Neurosci. 2008;3(3-4):261-75 [PMID: 18979380]
  21. Eur J Phys Rehabil Med. 2012 Jun;48(2):313-8 [PMID: 22522432]
  22. Brain. 1998 May;121 ( Pt 5):889-905 [PMID: 9619192]
  23. BMC Med. 2012 Jun 26;10:64 [PMID: 22730909]
  24. Neurosci Res. 2015 Jan;90:15-24 [PMID: 25455743]
  25. Neurocase. 2015;21(2):206-10 [PMID: 24571201]
  26. Neuropsychologia. 2006;44(4):610-21 [PMID: 16140346]
  27. Philos Trans R Soc Lond B Biol Sci. 2014 Apr 28;369(1644):20130289 [PMID: 24778381]
  28. Neuropsychologia. 2008;46(9):2371-82 [PMID: 18433807]
  29. Exp Brain Res. 1988;71(3):491-507 [PMID: 3416965]
  30. Soc Cogn Affect Neurosci. 2007 Jun;2(2):93-103 [PMID: 18985128]
  31. Pediatr Neurol. 2015 Oct;53(4):350-9 [PMID: 26231265]
  32. Med Hypotheses. 2012 Dec;79(6):790-8 [PMID: 22999736]
  33. Trends Cogn Sci. 2008 Jun;12(6):225-9 [PMID: 18479959]
  34. J Integr Neurosci. 2013 Mar;12(1):35-46 [PMID: 23621455]
  35. Neuroscientist. 2007 Dec;13(6):667-72 [PMID: 17911210]
  36. Soc Neurosci. 2008;3(3-4):334-47 [PMID: 18979389]
  37. Cortex. 2015 Jan;62:158-81 [PMID: 25433958]
  38. Biol Psychiatry. 2013 Apr 1;73(7):e9-11 [PMID: 23245746]
  39. J Neurosci. 2008 Jul 30;28(31):7726-7 [PMID: 18667604]
  40. Brain Res. 2009 Dec 22;1304:113-21 [PMID: 19782668]
  41. Pediatrics. 2007 Nov;120(5):1162-82 [PMID: 17967921]
  42. Science. 2009 Aug 14;325(5942):880-3 [PMID: 19679816]
  43. PLoS One. 2012;7(4):e32517 [PMID: 22505995]
  44. Hum Brain Mapp. 2015 Mar;36(3):1010-27 [PMID: 25366580]
  45. Cerebellum. 2008;7(3):406-16 [PMID: 18587625]
  46. Psychol Bull. 2007 Mar;133(2):310-27 [PMID: 17338602]
  47. J Cogn Neurosci. 2008 Sep;20(9):1611-23 [PMID: 18345991]
  48. Nat Neurosci. 2006 Jan;9(1):28-30 [PMID: 16327784]
  49. Nat Rev Neurosci. 2010 Jun;11(6):417-28 [PMID: 20445542]
  50. J Clin Neurosci. 2010 Oct;17(10):1239-43 [PMID: 20598548]
  51. Rev Neurosci. 2003;14(4):303-16 [PMID: 14640318]
  52. Front Syst Neurosci. 2011 Feb 22;5:10 [PMID: 21390284]
  53. JAMA Psychiatry. 2014 Jul 1;71(7):751-60 [PMID: 24740586]
  54. Philos Trans R Soc Lond B Biol Sci. 2014 Apr 28;369(1644):20130184 [PMID: 24778379]
  55. Brain Res Cogn Brain Res. 2005 Jul;24(2):190-8 [PMID: 15993757]
  56. Philos Trans R Soc Lond B Biol Sci. 2007 Apr 29;362(1480):659-69 [PMID: 17301027]
  57. Biol Psychiatry. 2010 Dec 15;68(12):1148-55 [PMID: 21130224]
  58. Neurosci Lett. 2013 Apr 12;540:43-55 [PMID: 23063951]
  59. Biol Psychiatry. 2016 Apr 15;79(8):676-84 [PMID: 26300272]
  60. Neuroreport. 2010 Apr 21;21(6):432-5 [PMID: 20220541]
  61. Curr Biol. 2010 Apr 27;20(8):750-6 [PMID: 20381353]
  62. Front Neurosci. 2015 Sep 01;9:296 [PMID: 26388713]
  63. J Clin Neurosci. 2015 Apr;22(4):664-9 [PMID: 25726458]
  64. Sci Am. 2006 Nov;295(5):62-9 [PMID: 17076085]
  65. Front Integr Neurosci. 2012 Dec 12;6:115 [PMID: 23248590]
  66. Neuroimage. 2012 Jan 2;59(1):556-64 [PMID: 21839178]
  67. Dev Neurosci. 2015;37(3):215-31 [PMID: 25895486]
  68. Synapse. 2014 Oct;68(10):468-73 [PMID: 24985713]
  69. Dev Cogn Neurosci. 2013 Jan;3:91-105 [PMID: 23245224]
  70. J Am Acad Child Adolesc Psychiatry. 2015 Jan;54(1):11-24 [PMID: 25524786]
  71. Nat Rev Neurosci. 2009 Jan;10(1):59-70 [PMID: 19096369]
  72. Res Autism Spectr Disord. 2014 Jan;8(1):44-51 [PMID: 24459534]
  73. Trends Cogn Sci. 1998 Dec 1;2(12):493-501 [PMID: 21227300]
  74. Neuropsychologia. 2015 Apr;70:442-54 [PMID: 25447372]
  75. Neurosci Biobehav Rev. 2014 Nov;47:177-93 [PMID: 25149267]
  76. Physiol Behav. 2010 Jun 1;100(3):268-76 [PMID: 20093134]
  77. Phys Life Rev. 2015 Mar;12:91-103 [PMID: 25465480]
  78. Neuron. 2004 Apr 22;42(2):335-46 [PMID: 15091347]
  79. Neuroimage Clin. 2015 Apr 15;8:170-9 [PMID: 26106541]
  80. Neurosci Biobehav Rev. 2008;32(4):811-30 [PMID: 18316124]
  81. Philos Trans R Soc Lond B Biol Sci. 2014 Apr 28;369(1644):20130176 [PMID: 24778373]
  82. Behaviour. 2014 Feb 1;151(2-3):297-313 [PMID: 25258451]
  83. Autism Res. 2008 Apr;1(2):73-90 [PMID: 19360654]
  84. Neurosci Biobehav Rev. 2011 Jan;35(3):894-902 [PMID: 20974171]
  85. J Neurodev Disord. 2013 May 02;5(1):12 [PMID: 23639144]
  86. Brain. 2015 Jul;138(Pt 7):2034-45 [PMID: 25935724]
  87. Hum Brain Mapp. 2004 Dec;23(4):200-9 [PMID: 15449355]
  88. J Neurophysiol. 2010 Aug;104(2):1077-89 [PMID: 20538772]
  89. Eur J Neurosci. 2001 Jan;13(2):400-4 [PMID: 11168545]
  90. PLoS One. 2013 Aug 21;8(8):e69886 [PMID: 23990890]
  91. Curr Biol. 2011 Feb 8;21(3):249-53 [PMID: 21256015]
  92. Autism Res. 2015 Jun;8(3):338-50 [PMID: 25626423]
  93. Acta Neuropathol Commun. 2014 Sep 18;2:141 [PMID: 25231243]
  94. Annu Rev Psychol. 1989;40:249-80 [PMID: 2648977]
  95. Philos Trans R Soc Lond B Biol Sci. 2014 Apr 28;369(1644):20130183 [PMID: 24778378]
  96. Neurology. 1985 Jun;35(6):866-74 [PMID: 4000488]
  97. J Vis Exp. 2011 Sep 12;(55): [PMID: 21931296]
  98. Neuroimage. 2002 Jun;16(2):331-48 [PMID: 12030820]
  99. Neurosci Biobehav Rev. 2010 Mar;34(4):575-83 [PMID: 19914284]
  100. Biol Psychiatry. 2014 Sep 1;76(5):356-7 [PMID: 25103540]
  101. Int J Psychophysiol. 2013 Jul;89(1):99-105 [PMID: 23756148]
  102. J Neurophysiol. 1997 Oct;78(4):2226-30 [PMID: 9325390]
  103. Autism Res. 2015 Feb;8(1):82-93 [PMID: 25381736]
  104. Phys Life Rev. 2015 Mar;12:123-5 [PMID: 25637139]
  105. J Autism Dev Disord. 2008 Nov;38(10):1989-97 [PMID: 18712466]
  106. Science. 2005 Apr 29;308(5722):662-7 [PMID: 15860620]
  107. J Neurodev Disord. 2015;7(1):12 [PMID: 25829969]
  108. Diagn Interv Imaging. 2012 Mar;93(3):139-47 [PMID: 22421278]
  109. Curr Opin Neurobiol. 2009 Dec;19(6):666-71 [PMID: 19880311]
  110. Neurosci Lett. 2013 Apr 12;540:15-20 [PMID: 23063953]
  111. Dev Sci. 2011 Mar;14(2):327-35 [PMID: 22213903]
  112. J Neurosci. 2014 Nov 5;34(45):14827-32 [PMID: 25378150]
  113. Brain. 1996 Apr;119 ( Pt 2):593-609 [PMID: 8800951]
  114. Autism Res. 2014 Apr;7(2):197-206 [PMID: 24515797]
  115. J Child Psychol Psychiatry. 2009 Aug;50(8):881-92 [PMID: 19508497]
  116. PLoS One. 2013 Oct 30;8(10):e77905 [PMID: 24205023]
  117. Phys Life Rev. 2011 Dec;8(4):410-37 [PMID: 22018722]
  118. Nat Rev Neurosci. 2010 Apr;11(4):264-74 [PMID: 20216547]
  119. Cell Mol Neurobiol. 2002 Apr;22(2):171-5 [PMID: 12363198]
  120. Philos Trans R Soc Lond B Biol Sci. 2014 Apr 28;369(1644):20130620 [PMID: 24778387]
  121. Autism. 2016 Feb;20(2):134-44 [PMID: 25769312]
  122. No To Hattatsu. 2014 Jul;46(4):281-6 [PMID: 25154225]
  123. Cell. 2015 Mar 12;160(6):1233-45 [PMID: 25728667]
  124. Front Hum Neurosci. 2014 Nov 25;8:957 [PMID: 25505401]
  125. Neurorehabil Neural Repair. 2014 Nov-Dec;28(9):874-84 [PMID: 24642381]
  126. Neuroimage. 2014 Feb 15;87:127-37 [PMID: 24140938]

MeSH Term

Autism Spectrum Disorder
Autistic Disorder
Female
Humans
Imitative Behavior
Male
Mirror Neurons
Social Behavior
Speech
Walking

Word Cloud

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