Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites.
Aditya S Paul, Cristina K Moreira, Brendan Elsworth, David R Allred, Manoj T Duraisingh
Author Information
Aditya S Paul: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Cristina K Moreira: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Brendan Elsworth: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
David R Allred: Department of Infectious Diseases and Pathology, University of Florida, Gainesville, Florida, USA Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Manoj T Duraisingh: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA mduraisi@hsph.harvard.edu.
The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in the Malaria Box library. We observed that these parasites share sensitivities to a large fraction of the same inhibitors and we identified compounds with strong babesiacidal activity.
References
PLoS One. 2013 Jun 17;8(6):e62906
[PMID: 23798988]
