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World journal of pediatrics : WJP
Nov, 2016;12 (4): 399-407.

Efficacy and safety of itraconazole use in infants.

Shuang Chen, Kai-Yi Sun, Xiao-Wei Feng, Xin Ran, Jebina Lama, Yu-Ping Ran
Author Information
  1. Shuang Chen: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, 610041, China.
  2. Kai-Yi Sun: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, 610041, China.
  3. Xiao-Wei Feng: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, 610041, China.
  4. Xin Ran: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, 610041, China.
  5. Jebina Lama: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, 610041, China.
  6. Yu-Ping Ran: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, 610041, China. ranyuping@vip.sina.com.
PMID: 27286691 DOI: 10.1007/s12519-016-0034-x

Abstract

BACKGROUND: Itraconazole has been used to treat fungal infections, in particular invasive fungal infections in infants or neonates in many countries.
DATA SOURCES: Literature search was conducted through Ovid EMBASE, PubMed, ISI Web of Science, CNKI and Google scholarship using the following key words: "pediatric" or "infant" or "neonate" and "fungal infection" in combination with "itraconazole". Based on the literature and our clinical experience, we outline the administration of itraconazole in infants in order to develop evidence-based pharmacotherapy.
RESULTS: Of 45 articles on the use of itraconazole in infancy, 13 are related to superficial fungal infections including tinea capitis, sporotrichosis, mucosal fungal infections and opportunistic infections. The other 32 articles are related to systemic fungal infections including candidiasis, aspergillosis, histoplasmosis, zygomycosis, trichosporonosis and opportunistic infections as caused by Myceliophthora thermophila.
CONCLUSION: Itraconazole is safe and effective at a dose of 5 mg/kg per day in a short duration of therapy for superficial fungal infections and 10 mg/kg per day for systemic fungal infections in infants. With a good compliance, it is cost-effective in treating infantile fungal infections. The profiles of adverse events induced by itraconazole in infants are similar to those in adults and children.

Keywords

infant itraconazole prophylaxis superficial fungal infections systemic fungal infections

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MeSH Term

Adolescent
Age Factors
Antifungal Agents
Child
Child, Preschool
China
Dose-Response Relationship, Drug
Drug Administration Schedule
Evidence-Based Medicine
Female
Fungemia
Humans
Infant
Itraconazole
Male
Mycoses
Patient Safety
Severity of Illness Index
Sex Factors
Treatment Outcome

Chemicals

Antifungal Agents
Itraconazole
Journal Article Review
Article has an altmetric score of 6

Word Cloud

Created with Highcharts 10.0.0infectionsfungalinfantsitraconazolesuperficialsystemicItraconazolearticlesuserelatedincludingopportunisticmg/kgperdayBACKGROUND:usedtreatparticularinvasiveneonatesmanycountriesDATASOURCES:LiteraturesearchconductedOvidEMBASEPubMedISIWebScienceCNKIGooglescholarshipusingfollowingkeywords:"pediatric""infant""neonate""fungalinfection"combination"itraconazole"Basedliteratureclinicalexperienceoutlineadministrationorderdevelopevidence-basedpharmacotherapyRESULTS:45infancy13tineacapitissporotrichosismucosal32candidiasisaspergillosishistoplasmosiszygomycosistrichosporonosiscausedMyceliophthorathermophilaCONCLUSION:safeeffectivedose5shortdurationtherapy10goodcompliancecost-effectivetreatinginfantileprofilesadverseeventsinducedsimilaradultschildrenEfficacysafetyinfantprophylaxis

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