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Nutrients
Jun 28, 2016;8 (7):

Mangiferin and Cancer: Mechanisms of Action.

Fuchsia Gold-Smith, Alyssa Fernandez, Karen Bishop
Author Information
  1. Fuchsia Gold-Smith: Auckland Cancer Society Research Center, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. fgol315@aucklanduni.ac.nz.
  2. Alyssa Fernandez: Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. afer098@aucklanduni.ac.nz.
  3. Karen Bishop: Auckland Cancer Society Research Center, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. k.bishop@auckland.ac.nz.
PMID: 27367721 DOI: 10.3390/nu8070396

Abstract

Mangiferin, a bioactive compound derived primarily from Anacardiaceae and Gentianaceae families and found in mangoes and honeybush tea, has been extensively studied for its therapeutic properties. Mangiferin has shown promising chemotherapeutic and chemopreventative potential. This review focuses on the effect of mangiferin on: (1) inflammation, with respect to NFκB, PPARү and the immune system; (2) cell cycle, the MAPK pathway G₂/M checkpoint; (3) proliferation and metastasis, and implications on β-catenin, MMPs, EMT, angiogenesis and tumour volume; (4) apoptosis, with a focus on Bax/Bcl ratios, intrinsic/extrinsic apoptotic pathways and telomerase activity; (5) oxidative stress, through Nrf2/ARE signalling, ROS elimination and catalase activity; and (6) efficacy of chemotherapeutic agents, such as oxaliplatin, etoposide and doxorubicin. In addition, the need to enhance the bioavailability and delivery of mangiferin are briefly addressed, as well as the potential for toxicity.

Keywords

NFκB bioavailability cancer cell cycle combination therapy hallmarks of cancer inflammation mangiferin nutraceuticals oxidative stress

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MeSH Term

Anacardiaceae
Animals
Antineoplastic Agents
Apoptosis
Cell Cycle
Cell Line, Tumor
Disease Models, Animal
Drug Synergism
Gentianaceae
Humans
Inflammation
Neoplasm Metastasis
Oxidative Stress
Plant Extracts
Toxicity Tests
Xanthones

Chemicals

Antineoplastic Agents
Plant Extracts
Xanthones
mangiferin
Journal Article Review
Article has an altmetric score of 133

Word Cloud

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