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Human vaccines & immunotherapeutics
12, 2016;12 (12): 3110-3112.

Mumps virus pathogenesis: Insights and knowledge gaps.

Sigrid Gouma, Marion P G Koopmans, Rob S van Binnendijk
Author Information
  1. Sigrid Gouma: a Centre for Infectious Disease Control , National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.
  2. Marion P G Koopmans: a Centre for Infectious Disease Control , National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.
  3. Rob S van Binnendijk: a Centre for Infectious Disease Control , National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.
PMID: 27455055 DOI: 10.1080/21645515.2016.1210745

Abstract

The recent mumps outbreaks among MMR vaccinated persons have raised questions about the biological mechanisms related to mumps symptoms and complications in the background of waning immunity. Contrary to other paramyxoviruses, the understanding of mumps virus pathogenesis is limited, and further in-depth clinical studies are required to provide answers to important research questions.

Keywords

MMR vaccination Mumps virus T cell immunity mucosal immunity orchitis parotitis symptoms viruria

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MeSH Term

Child
Child, Preschool
Humans
Knowledge
Mumps
Mumps virus
Journal Article
Article has an altmetric score of 10

Word Cloud

Created with Highcharts 10.0.0mumpsimmunityvirusMMRquestionssymptomsMumpsrecentoutbreaksamongvaccinatedpersonsraisedbiologicalmechanismsrelatedcomplicationsbackgroundwaningContraryparamyxovirusesunderstandingpathogenesislimitedin-depthclinicalstudiesrequiredprovideanswersimportantresearchpathogenesis:InsightsknowledgegapsvaccinationTcellmucosalorchitisparotitisviruria

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