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Developmental cell
07 25, 2016;38 (2): 147-60.

The Dynamics of Apoptotic Cell Clearance.

Michael R Elliott, Kodi S Ravichandran
Author Information
  1. Michael R Elliott: Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address: michael_elliott@urmc.rochester.edu.
  2. Kodi S Ravichandran: Department of Microbiology, Immunology, Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA; Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: ravi@virginia.edu.
PMID: 27459067 DOI: 10.1016/j.devcel.2016.06.029

Abstract

The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.

Keywords

apoptosis chemotaxis efferocytosis imaging immunity phagocytosis signal transduction

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Grants

  1. P01 HL120840/NHLBI NIH HHS
  2. R01 HD074981/NICHD NIH HHS
  3. R01 GM064709/NIGMS NIH HHS
  4. R01 AI114554/NIAID NIH HHS
  5. R01 GM107848/NIGMS NIH HHS

MeSH Term

Animals
Apoptosis
Humans
Phagocytosis
Signal Transduction
Journal Article Review Research Support, N.I.H., Extramural
Article has an altmetric score of 5

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