A quantile regression model for failure-time data with time-dependent covariates.

Malka Gorfine, Yair Goldberg, Ya'acov Ritov
Author Information
  1. Malka Gorfine: Department of Statistics and Operation Research, Tel Aviv University, Ramat Aviv, 6997801 Tel Aviv, Israel gorfinem@post.tau.ac.il.
  2. Yair Goldberg: Department of Statistics, University of Haifa, Mount Carmel, 31905 Haifa, Israel.
  3. Ya'acov Ritov: Department of Statistics, The Hebrew University of Jerusalem, Mount Scopus, 91905 Jerusalem, Israel and Department of Statistics, University of Michigan, Ann Arbor, MI 48194, USA.

Abstract

Since survival data occur over time, often important covariates that we wish to consider also change over time. Such covariates are referred as time-dependent covariates. Quantile regression offers flexible modeling of survival data by allowing the covariates to vary with quantiles. This article provides a novel quantile regression model accommodating time-dependent covariates, for analyzing survival data subject to right censoring. Our simple estimation technique assumes the existence of instrumental variables. In addition, we present a doubly-robust estimator in the sense of Robins and Rotnitzky (1992, Recovery of information and adjustment for dependent censoring using surrogate markers. In: Jewell, N. P., Dietz, K. and Farewell, V. T. (editors), AIDS Epidemiology. Boston: Birkhaäuser, pp. 297-331.). The asymptotic properties of the estimators are rigorously studied. Finite-sample properties are demonstrated by a simulation study. The utility of the proposed methodology is demonstrated using the Stanford heart transplant dataset.

Keywords

References

  1. Biometrics. 2002 Sep;58(3):643-9 [PMID: 12229999]
  2. J Am Stat Assoc. 2008 Jun 1;103(482):672-680 [PMID: 20376193]
  3. J Am Stat Assoc. 2003 Dec 1;98(464):1063-1078 [PMID: 21151838]

Grants

  1. P01 CA053996/NCI NIH HHS

MeSH Term

Computer Simulation
Heart Transplantation
Humans
Models, Statistical
Regression Analysis
Survival Analysis

Word Cloud

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