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Wiley interdisciplinary reviews. Developmental biology
01, 2017;6 (1):

Gene-environment interactions in development and disease.

C Lovely, Mindy Rampersad, Yohaan Fernandes, Johann Eberhart
Author Information
  1. C Lovely: Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
  2. Mindy Rampersad: Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
  3. Yohaan Fernandes: Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
  4. Johann Eberhart: Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
PMID: 27626243 DOI: 10.1002/wdev.247

Abstract

Developmental geneticists continue to make substantial jumps in our understanding of the genetic pathways that regulate development. This understanding stems predominantly from analyses of genetically tractable model organisms developing in laboratory environments. This environment is vastly different from that in which human development occurs. As such, most causes of developmental defects in humans are thought to involve multifactorial gene-gene and gene-environment interactions. In this review, we discuss how gene-environment interactions with environmental teratogens may predispose embryos to structural malformations. We elaborate on the growing number of gene-ethanol interactions that might underlie susceptibility to fetal alcohol spectrum disorders. WIREs Dev Biol 2017, 6:e247. doi: 10.1002/wdev.247 For further resources related to this article, please visit the WIREs website.

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Grants

  1. R01 AA023426/NIAAA NIH HHS
  2. U24 AA014811/NIAAA NIH HHS
  3. R01 DE020884/NIDCR NIH HHS
  4. R21 AA024043/NIAAA NIH HHS
  5. K99 AA023560/NIAAA NIH HHS

MeSH Term

Developmental Biology
Disease
Gene Expression Regulation, Developmental
Gene-Environment Interaction
Humans
Journal Article Review Research Support, N.I.H., Extramural
Article has an altmetric score of 6

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