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The Journal of experimental biology
12 15, 2016;219 (Pt 24): 3861-3865.

Dopaminergic inhibition of gonadotropin-releasing hormone neurons in the cichlid fish Astatotilapia burtoni.

Astra S Bryant, Anna K Greenwood, Scott A Juntti, Allie E Byrne, Russell D Fernald
Author Information
  1. Astra S Bryant: Department of Biology, Stanford University, Stanford, CA 94305, USA astra.bryant@gmail.com. ORCID
  2. Anna K Greenwood: Department of Biology, Stanford University, Stanford, CA 94305, USA.
  3. Scott A Juntti: Department of Biology, Stanford University, Stanford, CA 94305, USA.
  4. Allie E Byrne: Department of Biology, Stanford University, Stanford, CA 94305, USA.
  5. Russell D Fernald: Department of Biology, Stanford University, Stanford, CA 94305, USA.
PMID: 27742893 DOI: 10.1242/jeb.147637

Abstract

Dopamine regulates reproduction in part by modulating neuronal activity within the hypothalamic-pituitary-gonadal (HPG) axis. Previous studies suggested numerous mechanisms by which dopamine exerts inhibitory control over the HPG axis, ultimately changing the levels of sex steroids that regulate reproductive behaviors. However, it is not known whether these mechanisms are conserved across vertebrate species. In particular, it is unknown whether mechanisms underlying dopaminergic control of reproduction are shared between mammals and teleost fish. In mammals, dopamine directly inhibits gonadotropin-releasing hormone (GnRH1) hypothalamic neurons, the gatekeepers for activation of the HPG axis. Here, we demonstrate, for the first time in teleost fish, dopaminergic control of GnRH1 neurons via direct dopamine type-2-like receptor (D2R)-mediated inhibition within the hypothalamus. These results suggest that direct dopaminergic control of GnRH1 neurons via interactions in the hypothalamus is not exclusive to tetrapod reproductive control, but is likely conserved across vertebrate species.

Keywords

Dopamine GnRH HPG axis Hypothalamus Reproduction

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Grants

  1. R37 NS034950/NINDS NIH HHS
  2. R21 NS093277/NINDS NIH HHS
  3. R01 NS034950/NINDS NIH HHS
  4. R56 NS034950/NINDS NIH HHS
  5. F32 HD071755/NICHD NIH HHS

MeSH Term

Action Potentials
Animals
Cichlids
Dopamine
Female
Gonadotropin-Releasing Hormone
Male
Neurons
Preoptic Area
Receptors, Dopamine D1
Receptors, Dopamine D2
Sex Characteristics
Tyrosine 3-Monooxygenase

Chemicals

Receptors, Dopamine D1
Receptors, Dopamine D2
Gonadotropin-Releasing Hormone
Tyrosine 3-Monooxygenase
Dopamine
Journal Article Research Support, N.I.H., Extramural
Article has an altmetric score of 1

Word Cloud

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