Brain transcriptomes of honey bees () experimentally infected by two pathogens: Black queen cell virus and .
Vincent Doublet, Robert J Paxton, Cynthia M McDonnell, Emeric Dubois, Sabine Nidelet, Robin F A Moritz, Cédric Alaux, Yves Le Conte
Author Information
Vincent Doublet: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle (Salle), Germany; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany; Centre for Ecology and Conservation, University of Exeter, Penryn Campus, Penryn TR11 9FE, UK.
Robert J Paxton: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle (Salle), Germany; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany.
Cynthia M McDonnell: INRA, UR 406 Abeilles et Environnement, 84914 Avignon Cedex 09, France.
Emeric Dubois: MGX-Montpellier GenomiX, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094 Cedex 5 Montpellier, France.
Sabine Nidelet: MGX-Montpellier GenomiX, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094 Cedex 5 Montpellier, France.
Robin F A Moritz: Institut für Biologie, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle (Salle), Germany; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany.
Cédric Alaux: INRA, UR 406 Abeilles et Environnement, 84914 Avignon Cedex 09, France.
Yves Le Conte: INRA, UR 406 Abeilles et Environnement, 84914 Avignon Cedex 09, France.
Regulation of gene expression in the brain plays an important role in behavioral plasticity and decision making in response to external stimuli. However, both can be severely affected by environmental factors, such as parasites and pathogens. In honey bees, the emergence and re-emergence of pathogens and potential for pathogen co-infection and interaction have been suggested as major components that significantly impaired social behavior and survival. To understand how the honey bee is affected and responds to interacting pathogens, we co-infected workers with two prevalent pathogens of different nature, the positive single strand RNA virus Black queen cell virus (BQCV), and the Microsporidia , and explored gene expression changes in brains upon single infections and co-infections. Our data provide an important resource for research on honey bee diseases, and more generally on insect host-pathogen and pathogen-pathogen interactions. Raw and processed data are publicly available in the NCBI/GEO database: (http://www.ncbi.nlm.nih.gov/geo/) under accession number GSE81664.
