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01, 2017;8 (1): 32-39.

More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?

Diego M Presman, Gordon L Hager
Author Information
  1. Diego M Presman: a Laboratory of Receptor Biology and Gene Expression , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
  2. Gordon L Hager: a Laboratory of Receptor Biology and Gene Expression , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
PMID: 27764575 DOI: 10.1080/21541264.2016.1249045

Abstract

It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR-DNA complex as a tetramer.

Keywords

DNA binding dimer glucocorticoid receptor monomer steroid receptors tetramer

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MeSH Term

DNA
Models, Genetic
Models, Molecular
Protein Structure, Quaternary
Receptors, Glucocorticoid
Response Elements

Chemicals

Receptors, Glucocorticoid
DNA
Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Word Cloud

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