No End in Sight: Benzodiazepine Use in Older Adults in the United States.

Donovan T Maust, Helen C Kales, Ilse R Wiechers, Frederic C Blow, Mark Olfson
Author Information
  1. Donovan T Maust: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
  2. Helen C Kales: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
  3. Ilse R Wiechers: Northeast Program Evaluation Center, Office of Mental Health Operations, U.S. Department of Veterans Affairs, West Haven, Connecticut.
  4. Frederic C Blow: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
  5. Mark Olfson: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.

Abstract

OBJECTIVES: To establish the rate of new and continuation of benzodiazepine use in older adults seen by nonpsychiatrist physicians and to identify subpopulations at risk of new and continuation benzodiazepine use.
DESIGN: Cross-sectional analysis.
SETTING: National Ambulatory Medical Care Survey (2007-10).
PARTICIPANTS: Adults visiting office-based nonpsychiatrist physicians (n = 98,818) who were prescribed a benzodiazepine (new or continuation).
MEASUREMENTS: Percentage of benzodiazepine visits of all outpatient encounters according to patient age and corresponding annual visit rate per 1,000 population. Analysis was then limited to adults aged 65 and older, demographic, clinical, and visits characteristics were used to compare visits of benzodiazepine users with those of nonusers and visits of continuation users with those of new users.
RESULTS: The overall proportion of benzodiazepine visits ranged from 3.2% (95% confidence interval (CI) = 2.7-3.7) of those aged 18 to 34 to 6.6% (95% CI = 5.8-7.6) of those aged 80 and older, and the proportion of continuation visits increased with age, rising to 90.2% (95% CI = 86.2-93.1) of those aged 80 and older. The population-based visit rate ranged from 61.7 (95% CI = 50.7-72.7) per 1,000 persons in the youngest adults to 463.7 (95% CI = 385.4-542.0) in those aged 80 and older. Only 16.0% (95% CI = 13.5-18.8) of continuation users had any mental health diagnosis. Of all benzodiazepine users, fewer than 1% (95% CI = .4-1.8) were provided or referred to psychotherapy, and 10.0% (95% CI = 7. 2-13.3) were also prescribed an opioid.
CONCLUSION: In the United States, few older adult benzodiazepine users receive a clinical mental health diagnosis, and almost none are provided or referred to psychotherapy. Prescribing to older adults continues despite decades of evidence documenting safety concerns, effective alternative treatments, and effective methods for tapering even chronic users.

Keywords

References

  1. BMJ. 2011 Mar 11;342:d1199 [PMID: 21398351]
  2. J Am Geriatr Soc. 2015 Nov;63(11):2227-46 [PMID: 26446832]
  3. Vital Health Stat 2. 1979 Feb;(78):i-vi, 1-63 [PMID: 433160]
  4. Chest. 2005 Apr;127(4):1205-11 [PMID: 15821196]
  5. Am J Psychiatry. 2009 Aug;166(8):875-81 [PMID: 19570931]
  6. Am J Psychiatry. 2002 Jan;159(1):5-11 [PMID: 11772681]
  7. Am J Geriatr Psychiatry. 2011 Oct;19(10):851-8 [PMID: 21946801]
  8. Br J Psychiatry. 2014 Feb;204(2):98-107 [PMID: 24493654]
  9. Psychiatr Clin North Am. 2005 Dec;28(4):871-96, ix [PMID: 16325733]
  10. Gen Hosp Psychiatry. 2006 Sep-Oct;28(5):374-8 [PMID: 16950371]
  11. Am J Psychiatry. 2004 Feb;161(2):332-42 [PMID: 14754783]
  12. Am J Psychiatry. 2002 Nov;159(11):1914-20 [PMID: 12411228]
  13. J Am Geriatr Soc. 2009 Feb;57(2):243-50 [PMID: 19207141]
  14. BMJ. 2014 Jan 30;348:g445 [PMID: 24482539]
  15. Drugs Aging. 2012 Aug 1;29(8):639-58 [PMID: 22812538]
  16. J Am Geriatr Soc. 2000 Jul;48(7):811-6 [PMID: 10894322]
  17. JAMA Psychiatry. 2014 Feb;71(2):176-81 [PMID: 24337499]
  18. J Am Geriatr Soc. 2012 Feb;60(2):218-29 [PMID: 22283717]
  19. Drug Saf. 2011 Feb 1;34(2):125-56 [PMID: 21247221]
  20. J Gen Intern Med. 2007 Mar;22(3):303-7 [PMID: 17356959]
  21. J Gen Intern Med. 1998 Apr;13(4):243-50 [PMID: 9565387]
  22. J Clin Epidemiol. 1996 Sep;49(9):1067-73 [PMID: 8780618]
  23. JAMA Intern Med. 2014 Jun;174(6):890-8 [PMID: 24733354]
  24. BMJ. 2014 Sep 09;349:g5205 [PMID: 25208536]
  25. JAMA Intern Med. 2015 Sep;175(9):1461-72 [PMID: 26147487]
  26. JAMA Psychiatry. 2015 Feb;72(2):136-42 [PMID: 25517224]
  27. Am J Geriatr Psychiatry. 2003 Sep-Oct;11(5):568-76 [PMID: 14506091]
  28. J Gen Intern Med. 2007 Aug;22(8):1094-100 [PMID: 17492325]
  29. J Anxiety Disord. 2008;22(1):108-16 [PMID: 17321717]
  30. J Clin Psychopharmacol. 2002 Jun;22(3):285-93 [PMID: 12006899]
  31. Am J Psychiatry. 1998 May;155(5 Suppl):1-34 [PMID: 9585731]
  32. J Am Geriatr Soc. 2011 Mar;59(3):430-8 [PMID: 21391934]
  33. CMAJ. 2003 Nov 11;169(10):1015-20 [PMID: 14609970]
  34. JAMA. 2013 Feb 20;309(7):657-9 [PMID: 23423407]
  35. World J Biol Psychiatry. 2008;9(4):248-312 [PMID: 18949648]
  36. Am J Psychiatry. 2001 Jun;158(6):892-8 [PMID: 11384896]
  37. Arch Intern Med. 2009 Nov 23;169(21):1952-60 [PMID: 19933955]

Grants

  1. K08 AG048321/NIA NIH HHS

MeSH Term

Aged
Aged, 80 and over
Benzodiazepines
Cross-Sectional Studies
Female
Health Care Surveys
Humans
Male
Practice Patterns, Physicians'
United States

Chemicals

Benzodiazepines

Word Cloud

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