Introduction of standard measles vaccination in an urban African community in 1979 and overall child survival: a reanalysis of data from a cohort study.
Søren Wengel Mogensen, Peter Aaby, Lars Smedman, Cesário L Martins, Amabelia Rodrigues, Christine S Benn, Henrik Ravn
Author Information
Søren Wengel Mogensen: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
Peter Aaby: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
Lars Smedman: Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Cesário L Martins: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
Amabelia Rodrigues: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
Christine S Benn: Research Centre for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
Henrik Ravn: Research Centre for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
OBJECTIVE: To examine the effect of the first introduction of measles vaccine (MV) in Guinea-Bissau in 1979. SETTING: Urban community study of the anthropometric status of all children under 6 years of age. PARTICIPANTS: The study cohort included 1451 children in December 1978; 82% took part in the anthropometric survey. The cohort was followed for 2 years. INTERVENTION: In December 1979, the children were re-examined anthropometrically. The participating children, aged 6 months to 6 years, were offered MV if they did not have a history of measles infection. There were no routine vaccinations in 1979-1980. PRIMARY AND SECONDARY OUTCOME MEASURES: Age-adjusted mortality rate ratios (MRRs) for measles vaccinated and not vaccinated children; changes in nutritional status. RESULTS: The nutritional status deteriorated significantly from 1978 to 1979. Nonetheless, children who received MV at the December 1979 examination had significantly lower mortality in the following year (1980) compared with the children who had been present in the December 1978 examination but were not measles vaccinated. Among children still living in the community in December 1979, measles-vaccinated children aged 6-71 months had a mortality rate of 18/1000 person-years during the following year compared with 51/1000 person-years for absent children who were not measles vaccinated (MRR=0.30 (0.12-0.73)). The effect of MV was not explained by prevention of measles infection as the unvaccinated children did not die of measles infection. CONCLUSIONS: MV may have beneficial non-specific effects on child survival not related to the prevention of measles infection.
