Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration.
J P van den Berg, H E M Vereecke, J H Proost, D J Eleveld, J K G Wietasch, A R Absalom, M M R F Struys
Author Information
J P van den Berg: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands j.p.van.den.berg@umcg.nl.
H E M Vereecke: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
J H Proost: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
D J Eleveld: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
J K G Wietasch: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
A R Absalom: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
M M R F Struys: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.
