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Roux's archives of developmental biology : the official organ of the EDBO
Jul, 1988;197 (4): 239-246.

Maternal and zygotic requirement for thepolyhomeotic complex genetic locus inDrosophila.

Jean-Maurice Dura, Janet Deatrick, Neel B Randsholt, Hugh W Brock, Pedro Santamaria
Author Information
  1. Jean-Maurice Dura: Centre de Génétique Moléculaire, C.N.R.S., F-91190, Gif-sur-Yvette, France.
  2. Janet Deatrick: Centre de Génétique Moléculaire, C.N.R.S., F-91190, Gif-sur-Yvette, France.
  3. Neel B Randsholt: Centre de Génétique Moléculaire, C.N.R.S., F-91190, Gif-sur-Yvette, France.
  4. Hugh W Brock: Centre de Génétique Moléculaire, C.N.R.S., F-91190, Gif-sur-Yvette, France.
  5. Pedro Santamaria: Centre de Génétique Moléculaire, C.N.R.S., F-91190, Gif-sur-Yvette, France.
PMID: 28305632 DOI: 10.1007/BF02439431

Abstract

The complex genetic locuspolyhomeotic (ph) is a member of thePolycomb (Pc)-group of genes and as such is required for the normal expression of ANT-C and BX-C genes. It also has probably other functions since amorphicph alleles display a cell death phenotype in the ventral epidermis of 12-h-old embryos. Here it is shown that lethal alleles ofph (amorph and strong hypomorph) show transformation of most of their segments towards AB8. Theph product is required autonomously in imaginal cells. The total lack ofph function prevents viability of the cuticular derivatives of these cells.ph has a strong maternal effect on segmental identity and epidermal development that can not be rescued by one paternally supplied dose ofph in the zygote. These phenotypes differ substantially from those of previously describedPc-group genes. AmongPc-group genes,ph seems to be the only one that is strongly required both maternally and zygotically for normal embryonic development.

Keywords

Clonal analysis Drosophila Embryology Epidermal development Homeosis

References

  1. Roux Arch Dev Biol. 1987 Mar;196 (3):141-157 [PMID: 28305837]
  2. Nature. 1985 Jan 10-18;313(5998):108-13 [PMID: 3917555]
  3. Genetics. 1984 Dec;108(4):927-39 [PMID: 17246244]
  4. Cell. 1983 Nov;35(1):27-34 [PMID: 6627397]
  5. Wilehm Roux Arch Dev Biol. 1983 Mar;192(2):62-74 [PMID: 28305500]
  6. Nature. 1981 Sep 3;293(5827):36-41 [PMID: 7266657]
  7. Science. 1985 Sep 20;229(4719):1236-42 [PMID: 3898362]
  8. Dev Biol. 1979 Dec;73(2):239-55 [PMID: 115734]
  9. Roux Arch Dev Biol. 1986 Sep;195(7):417-432 [PMID: 28305404]
  10. Mol Gen Genet. 1985;198(2):213-20 [PMID: 3920476]
  11. EMBO J. 1985 Dec 1;4(12):3259-64 [PMID: 2419125]
  12. Nature. 1980 Oct 30;287(5785):795-801 [PMID: 6776413]
  13. Genetics. 1982 Sep;102(1):49-70 [PMID: 6813190]
  14. Cell. 1986 Oct 24;47(2):311-21 [PMID: 2876779]
  15. Dev Biol. 1983 Dec;100(2):399-411 [PMID: 6418587]
  16. Cell. 1986 Mar 14;44(5):739-48 [PMID: 3081265]
  17. Genetics. 1980 Jun;95(2):383-97 [PMID: 17249042]
  18. J Embryol Exp Morphol. 1983 Aug;76:297-331 [PMID: 6631324]
  19. Nature. 1978 Dec 7;276(5688):565-70 [PMID: 103000]
  20. Nature. 1984 Jan 19-25;307(5948):287-9 [PMID: 6420705]
  21. Cell. 1986 Oct 24;47(2):297-309 [PMID: 2876778]
  22. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4500-4 [PMID: 3110768]
  23. Dev Biol. 1975 Feb;42(2):211-21 [PMID: 1116643]
  24. Cell. 1981 Oct;26(1 Pt 1):3-10 [PMID: 7034957]
  25. Genetics. 1980 Jan;94(1):115-33 [PMID: 17248988]
  26. Genetics. 1980 Jun;95(2):367-81 [PMID: 17249041]
  27. Genetics. 1983 Oct;105(2):309-25 [PMID: 17246162]
  28. Cell. 1985 Dec;43(2 Pt 1):507-19 [PMID: 3935322]
  29. Dev Biol. 1979 Jan;68(1):96-109 [PMID: 108157]
  30. Cell. 1987 Dec 4;51(5):829-39 [PMID: 2890438]
  31. Annu Rev Genet. 1986;20:147-73 [PMID: 2880555]
  32. Stain Technol. 1977 Mar;52(2):89-95 [PMID: 69341]
  33. Dev Biol. 1983 May;97(1):34-47 [PMID: 6404678]
  34. Nature. 1986 Dec 11-17;324(6097):592-7 [PMID: 2878371]
  35. Cell. 1984 Jul;37(3):815-23 [PMID: 6430566]
  36. Annu Rev Cell Biol. 1986;2:49-80 [PMID: 2881561]
  37. Dev Biol. 1986 Dec;118(2):442-56 [PMID: 3098596]
  38. Genetics. 1981 Nov-Dec;99(3-4):429-41 [PMID: 6806142]
  39. Wilehm Roux Arch Dev Biol. 1982 Jan;191(1):42-55 [PMID: 28305421]
  40. Dev Biol. 1977 Jun;57(2):403-16 [PMID: 406152]
Journal Article

Word Cloud

Created with Highcharts 10.0.0genesphrequiredofphdevelopmentcomplexgeneticnormalallelesstrongcellsonelocuspolyhomeoticmemberthePolycombPc-groupexpressionANT-CBX-Calsoprobablyfunctionssinceamorphicphdisplaycelldeathphenotypeventralepidermis12-h-oldembryosshownlethalamorphhypomorphshowtransformationsegmentstowardsAB8ThephproductautonomouslyimaginaltotallackfunctionpreventsviabilitycuticularderivativesmaternaleffectsegmentalidentityepidermalcanrescuedpaternallysupplieddosezygotephenotypesdiffersubstantiallypreviouslydescribedPc-groupAmongPc-groupseemsstronglymaternallyzygoticallyembryonicMaternalzygoticrequirementthepolyhomeoticlocusinDrosophilaClonalanalysisDrosophilaEmbryologyEpidermalHomeosis

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