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Cell
03 23, 2017;169 (1): 24-34.

The Upsides and Downsides of Organelle Interconnectivity.

Daniel E Gottschling, Thomas Nyström
Author Information
  1. Daniel E Gottschling: Calico Life Sciences, South San Francisco, CA 94080, USA. Electronic address: dang@calicolabs.com.
  2. Thomas Nyström: Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. Electronic address: thomas.nystrom@cmb.gu.se.
PMID: 28340346 DOI: 10.1016/j.cell.2017.02.030

Abstract

Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast. These routes are reviewed here in the context of sub-system proteostasis and complex adaptive systems theory.

Keywords

aging inter-organelle communication protein quality control yeast

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Grants

  1. R01 AG023779/NIA NIH HHS
  2. R01 AG037512/NIA NIH HHS

MeSH Term

Aging
Animals
Cell Division
Humans
Organelles
Proteins
Saccharomyces cerevisiae
Signal Transduction

Chemicals

Proteins
Journal Article Review

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