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Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale
Feb, 2017;37 (1): 17-24.

Overexpression of chromatin assembly factor-1/p60 predicts biological behaviour of laryngeal carcinomas.

M Mesolella, B Iorio, M Landi, M Cimmino, G Ilardi, M Iengo, M Mascolo
Author Information
  1. M Mesolella: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
  2. B Iorio: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
  3. M Landi: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
  4. M Cimmino: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
  5. G Ilardi: Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy.
  6. M Iengo: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
  7. M Mascolo: Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy.
PMID: 28374866 DOI: 10.14639/0392-100X-867

Abstract

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

Keywords

CAF-1/p60 Carcinoma in situ Dysplasia Laryngeal cancer Prognostic factor Tumoural marker

References

  1. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12183-8 [PMID: 14519857]
  2. Oncol Rep. 2011 Jan;25(1):13-22 [PMID: 21109952]
  3. DNA Repair (Amst). 2009 Feb 1;8(2):262-73 [PMID: 19059499]
  4. Mol Cell Biol. 2002 Jan;22(2):614-25 [PMID: 11756556]
  5. Mol Cell Biol. 2000 Feb;20(4):1206-18 [PMID: 10648606]
  6. Cancer Res. 2004 Apr 1;64(7):2371-81 [PMID: 15059888]
  7. Plant Cell. 2006 Oct;18(10):2431-42 [PMID: 16980538]
  8. Eur J Biochem. 2004 Jun;271(12):2335-49 [PMID: 15182349]
  9. Mol Cell Biol. 2001 Mar;21(6):1953-61 [PMID: 11238931]
  10. Cell. 1996 Oct 4;87(1):95-104 [PMID: 8858152]
  11. J Biol Chem. 1999 Jun 4;274(23):16646-53 [PMID: 10347232]
  12. Oncol Lett. 2014 Dec;8(6):2501-2504 [PMID: 25364416]
  13. Cell. 1999 Feb 19;96(4):575-85 [PMID: 10052459]
  14. Histopathology. 2010 Nov;57(5):716-24 [PMID: 21083601]
  15. Mol Biol Cell. 2007 Jan;18(1):129-41 [PMID: 17065558]
  16. Nucleic Acids Res. 2012 Dec;40(22):11229-39 [PMID: 23034810]
  17. Nat Clin Pract Endocrinol Metab. 2007 Jul;3(7):539-46 [PMID: 17581623]
  18. Cell. 1996 Sep 20;86(6):887-96 [PMID: 8808624]
  19. CA Cancer J Clin. 2015 Mar;65(2):87-108 [PMID: 25651787]
  20. Mutat Res. 2007 May 1;618(1-2):52-64 [PMID: 17303193]
  21. J Biol Chem. 2000 Nov 10;275(45):35512-21 [PMID: 10938080]
  22. Oncol Lett. 2016 Apr;11(4):2595-2598 [PMID: 27073523]
  23. Histopathology. 2012 Dec;61(6):1089-105 [PMID: 22882088]
  24. J Neural Transm Suppl. 2003;(67):117-28 [PMID: 15068244]
  25. Eur Arch Otorhinolaryngol. 2000;257(4):227-31 [PMID: 10867840]
  26. Mol Cell Biol. 2004 Apr;24(7):2853-62 [PMID: 15024074]
  27. EMBO Rep. 2002 Apr;3(4):329-34 [PMID: 11897662]
  28. J Cell Biol. 1999 Dec 13;147(6):1153-66 [PMID: 10601331]
  29. Cell. 2004 Jan 9;116(1):51-61 [PMID: 14718166]
  30. Histopathology. 2009 Apr;54(5):580-9 [PMID: 19309489]
  31. Histopathology. 2007 Jun;50(7):911-9 [PMID: 17543081]
  32. BMC Cancer. 2010 Feb 24;10:63 [PMID: 20178651]

MeSH Term

Adult
Aged
Aged, 80 and over
Carcinoma in Situ
Carcinoma, Squamous Cell
Chromatin Assembly Factor-1
Female
Humans
Laryngeal Neoplasms
Male
Middle Aged

Chemicals

Chromatin Assembly Factor-1
Journal Article
Article has an altmetric score of 1

Word Cloud

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