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Lipids in health and disease
May 02, 2017;16 (1): 84.

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders.

Muhammad Imran, Muhammad Sajid Arshad, Masood Sadiq Butt, Joong-Ho Kwon, Muhammad Umair Arshad, Muhammad Tauseef Sultan
Author Information
  1. Muhammad Imran: Department of Diet and Nutritional Sciences, Imperial College of Business Studies, Lahore, Pakistan.
  2. Muhammad Sajid Arshad: Institute of Home and Food Sciences, Government College University, Faisalabad, 36000, Pakistan. sajid_ft@yahoo.com.
  3. Masood Sadiq Butt: National institute of Food Science and Technology, University of Agriculture Faisalabad, Faisalabad, Pakistan.
  4. Joong-Ho Kwon: School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566, Republic of South Korea.
  5. Muhammad Umair Arshad: Institute of Home and Food Sciences, Government College University, Faisalabad, 36000, Pakistan.
  6. Muhammad Tauseef Sultan: Department of Food Science and Technology, Bahauddin Zakariya University, Multan, Pakistan.
PMID: 28464819 DOI: 10.1186/s12944-017-0449-y

Abstract

The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.

Keywords

Bioactive molecules Health claims Human cancers Mangiferin Nutrition Toxicity

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MeSH Term

Anti-Inflammatory Agents
Antineoplastic Agents, Phytogenic
Antioxidants
Cardiovascular Diseases
Cognitive Dysfunction
Diabetes Mellitus, Type 2
Humans
Hyperlipidemias
Hypoglycemic Agents
Mangifera
Neoplasms
Neuralgia
Nootropic Agents
Oxidative Stress
Xanthones

Chemicals

Anti-Inflammatory Agents
Antineoplastic Agents, Phytogenic
Antioxidants
Hypoglycemic Agents
Nootropic Agents
Xanthones
mangiferin
Journal Article Review
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Word Cloud

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