Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans.
Tim Snijders, Joshua P Nederveen, Lex B Verdijk, Alfons J H M Houben, Gijs H Goossens, Gianna Parise, Luc J C van Loon
Author Information
Tim Snijders: Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Joshua P Nederveen: Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Lex B Verdijk: Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Alfons J H M Houben: Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, The Netherlands.
Gijs H Goossens: Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Gianna Parise: Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Luc J C van Loon: Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults. A skeletal muscle biopsy was taken from the of 22 healthy (nondiabetic) male older adults. In addition, all participants underwent an Oral Glucose Tolerance Test (OGTT). Muscle fiber capillarization was assessed by immunohistochemistry. Participants were divided into a group with relatively low (LOW) or high (HIGH) muscle fiber capillarization (capillary-to-fiber perimeter exchange (CFPE) index), based on the median value for the entire group. All participants were healthy, nonobese, and had a normal glucose tolerance, according to the individual OGTT results. Whereas no differences in blood glucose concentrations were observed between groups during the OGTT, the postprandial increase in plasma insulin concentrations was significantly greater in the LOW compared to the HIGH muscle fiber capillarization group ( < 0.05). Skeletal muscle fiber capillarization may determine insulin sensitivity in humans.
