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Frontiers in neuroscience
2017;11 304.

Minimal Effects of Age and Exposure to a Noisy Environment on Hearing in Alpha9 Nicotinic Receptor Knockout Mice.

Amanda M Lauer
Author Information
  1. Amanda M Lauer: Department of Otolaryngology-HNS, Center for Hearing and Balance, Johns Hopkins University School of MedicineBaltimore, MD, United States.
PMID: 28626386 DOI: 10.3389/fnins.2017.00304

Abstract

Studies have suggested a role of weakened medial olivocochlear (OC) efferent feedback in accelerated hearing loss and increased susceptibility to noise. The present study investigated the progression of hearing loss with age and exposure to a noisy environment in medial OC-deficient mice. Alpha9 nicotinic acetylcholine receptor knockout (α9KO) and wild types were screened for hearing loss using auditory brainstem responses. α9KO mice housed in a quiet environment did not show increased hearing loss compared to wild types in young adulthood and middle age. Challenging the medial OC system by housing in a noisy environment did not increase hearing loss in α9KO mice compared to wild types. ABR wave 1 amplitudes also did not show differences between α9KO mice and wild types. These data suggest that deficient medial OC feedback does not result in early onset of hearing loss.

Keywords

age alpha9 nicotinic acetylcholine receptor auditory efferent hearing loss noise olivocochlear

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Grants

  1. F32 DC009353/NIDCD NIH HHS
  2. P30 DC005211/NIDCD NIH HHS
  3. R03 DC012352/NIDCD NIH HHS
  4. T32 DC000023/NIDCD NIH HHS
Journal Article
Article has an altmetric score of 1

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