Learning from Adversity?

Robert B Bourret
Author Information
  1. Robert B Bourret: Department of Microbiology & Immunology, University of North Carolina, Chapel Hill, North Carolina, USA bourret@med.unc.edu.

Abstract

Many two-component regulatory systems, including PhoRB, are positively autoregulated, so stimuli result in an increase in the concentration of signaling proteins. When the quantity of signaling proteins depends on exposure history, how do past conditions affect future responses to stimuli? Hoffer et al. (J. Bacteriol. 183:4914-4917, 2001, https://doi.org/doi:10.1128/JB.183.16.4914-4917.2001) previously reported that bacteria "learn" from phosphate starvation and respond more rapidly to subsequent episodes of starvation. Gao et al. (J. Bacteriol. 199:e00390-17, 2017, https://doi.org/doi:10.1128/JB.00390-17) describe another aspect of hysteresis in the PhoRB regulon. Phosphate starvation also leads to a global decline in transcription, counteracting the effects of positive autoregulation and resulting in a similar net response (homeostasis), regardless of exposure history.

Keywords

References

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Grants

  1. R01 GM050860/NIGMS NIH HHS

MeSH Term

Bacterial Proteins
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Phosphates
Signal Transduction
Transcription Factors

Chemicals

Bacterial Proteins
Escherichia coli Proteins
PhoB protein, E coli
Phosphates
Transcription Factors
PhoR protein, Bacteria

Word Cloud

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