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Magnetic resonance in medicine
04, 2018;79 (4): 2367-2378.

Simultaneous magnetic resonance diffusion and pseudo-diffusion tensor imaging.

Meghdoot Mozumder, Leandro Beltrachini, Quinten Collier, Jose M Pozo, Alejandro F Frangi
Author Information
  1. Meghdoot Mozumder: Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Department of Electronic and Electrical Engineering, The University of Sheffield, Sheffield, UK.
  2. Leandro Beltrachini: Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Department of Electronic and Electrical Engineering, The University of Sheffield, Sheffield, UK.
  3. Quinten Collier: iMinds Vision Lab, Department of Physics, University of Antwerp (CDE), Antwerpen, Belgium.
  4. Jose M Pozo: Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Department of Electronic and Electrical Engineering, The University of Sheffield, Sheffield, UK.
  5. Alejandro F Frangi: Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Department of Electronic and Electrical Engineering, The University of Sheffield, Sheffield, UK.
PMID: 28714249 DOI: 10.1002/mrm.26840

Abstract

PURPOSE: An emerging topic in diffusion magnetic resonance is imaging blood microcirculation alongside water diffusion using the intravoxel incoherent motion (IVIM) model. Recently, a combined IVIM diffusion tensor imaging (IVIM-DTI) model was proposed, which accounts for both anisotropic pseudo-diffusion due to blood microcirculation and anisotropic diffusion due to tissue microstructures. In this article, we propose a robust IVIM-DTI approach for simultaneous diffusion and pseudo-diffusion tensor imaging.
METHODS: Conventional IVIM estimation methods can be broadly divided into two-step (diffusion and pseudo-diffusion estimated separately) and one-step (diffusion and pseudo-diffusion estimated simultaneously) methods. Here, both methods were applied on the IVIM-DTI model. An improved one-step method based on damped Gauss-Newton algorithm and a Gaussian prior for the model parameters was also introduced. The sensitivities of these methods to different parameter initializations were tested with realistic in silico simulations and experimental in vivo data.
RESULTS: The one-step damped Gauss-Newton method with a Gaussian prior was less sensitive to noise and the choice of initial parameters and delivered more accurate estimates of IVIM-DTI parameters compared to the other methods.
CONCLUSION: One-step estimation using damped Gauss-Newton and a Gaussian prior is a robust method for simultaneous diffusion and pseudo-diffusion tensor imaging using IVIM-DTI model. Magn Reson Med 79:2367-2378, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords

Magnetic resonance imaging diffusion intravoxel incoherent motion perfusion

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MeSH Term

Algorithms
Anisotropy
Brain
Computer Simulation
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Healthy Volunteers
Humans
Image Interpretation, Computer-Assisted
Microcirculation
Motion
Normal Distribution
Reproducibility of Results
Signal-To-Noise Ratio
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 4

Word Cloud

Created with Highcharts 10.0.0diffusionimagingpseudo-diffusionmodelIVIM-DTImethodstensorresonanceusingIVIMone-stepmethoddampedGauss-NewtonGaussianpriorparametersMagneticmagneticbloodmicrocirculationintravoxelincoherentmotionanisotropicduearticlerobustsimultaneousestimationestimatedResonanceMedicinePURPOSE:emergingtopicalongsidewaterRecentlycombinedproposedaccountstissuemicrostructuresproposeapproachMETHODS:Conventionalcanbroadlydividedtwo-stepseparatelysimultaneouslyappliedimprovedbasedalgorithmalsointroducedsensitivitiesdifferentparameterinitializationstestedrealisticsilicosimulationsexperimentalvivodataRESULTS:lesssensitivenoisechoiceinitialdeliveredaccurateestimatescomparedCONCLUSION:One-stepMagnResonMed79:2367-23782018©2017AuthorspublishedWileyPeriodicalsIncbehalfInternationalSocietyopenaccesstermsCreativeCommonsAttributionLicensepermitsusedistributionreproductionmediumprovidedoriginalworkproperlycitedSimultaneousperfusion

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