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Clinical interventions in aging
2017;12 1049-1054.

Kidney function and cognitive decline in an oldest-old Chinese population.

Kunhao Bai, Yujing Pan, Fanghong Lu, Yingxin Zhao, Jinwei Wang, Luxia Zhang
Author Information
  1. Kunhao Bai: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.
  2. Yujing Pan: Renal Division, Department of Medicine, Peking University International Hospital, Beijing, People's Republic of China.
  3. Fanghong Lu: Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China.
  4. Yingxin Zhao: Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China.
  5. Jinwei Wang: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.
  6. Luxia Zhang: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.
PMID: 28740370 DOI: 10.2147/CIA.S134205

Abstract

BACKGROUND: Early-stage chronic kidney disease has been suggested to be correlated with cognitive decline, but the association has rarely been explored in the oldest old.
SUBJECTS AND METHODS: This prospective study included 284 Chinese participants aged 80 years or older with serum creatinine levels <150 µmol/L. The median follow-up time was 3.3 years, and 247 (87.0%) participants provided valid data at their last visit. Kidney function was evaluated by measuring the estimated glomerular filtration rate (eGFR) at baseline, and cognitive function was evaluated using the Mini-Mental State Examination (MMSE) at both baseline and annual visits. A reliable decrease in the MMSE score over the follow-up period was observed based on a Reliable Change Index of 1.645 (equivalent to a 90% confidence interval [CI]), which was used to define cognitive decline. Poisson regression models were built to analyze the association between baseline kidney function and cognitive decline.
RESULTS: A total of 18 (7.3%) cases of incident cognitive decline were observed during the follow-up period. After adjusting for potential confounders, the relative risk of developing cognitive decline was 4.03 (95% CI 1.09-13.81) among participants with an eGFR of 30-59 mL/min/1.73 m compared to participants with an eGFR of ≥60 mL/min/1.73 m.
CONCLUSION: Early-stage chronic kidney disease was correlated with cognitive decline in an oldest-old Chinese population.

Keywords

chronic kidney disease cognitive decline oldest old

References

  1. Neurology. 2009 Sep 22;73(12):920-7 [PMID: 19657107]
  2. Neurology. 2000;54(11 Suppl 5):S4-9 [PMID: 10854354]
  3. Lancet. 1997 Jun 21;349(9068):1793-6 [PMID: 9269213]
  4. J Am Soc Nephrol. 2005 Jul;16(7):2127-33 [PMID: 15888561]
  5. J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1379-86 [PMID: 22960475]
  6. Am J Epidemiol. 2004 Apr 1;159(7):702-6 [PMID: 15033648]
  7. Adv Chronic Kidney Dis. 2008 Apr;15(2):123-32 [PMID: 18334236]
  8. Hypertension. 2005 Jul;46(1):200-4 [PMID: 15911742]
  9. J Am Geriatr Soc. 2008 Nov;56(11):2082-8 [PMID: 18795984]
  10. J Consult Clin Psychol. 1999 Aug;67(4):594-8 [PMID: 10450632]
  11. J Am Geriatr Soc. 2012 Jul;60(7):1208-14 [PMID: 22702744]
  12. Kidney Int. 2004 Feb;65(2):649-53 [PMID: 14717937]
  13. Nephrol Dial Transplant. 2009 Oct;24(10):3144-50 [PMID: 19461010]
  14. Drugs Aging. 2001;18(3):151-64 [PMID: 11302283]
  15. J Psychiatr Res. 1975 Nov;12(3):189-98 [PMID: 1202204]
  16. Am J Nephrol. 2010;32(2):117-21 [PMID: 20714128]
  17. N Engl J Med. 2008 May 1;358(18):1887-98 [PMID: 18378519]
  18. Neurology. 2009 Sep 22;73(12):916-7 [PMID: 19692675]
  19. Neurobiol Aging. 2006 Feb;27(2):278-84 [PMID: 15893409]
  20. N Engl J Med. 2002 Feb 14;346(7):476-83 [PMID: 11844848]
  21. J Am Soc Nephrol. 2009 Nov;20(11):2427-32 [PMID: 19729443]
  22. J Am Soc Nephrol. 2006 Oct;17 (10 ):2937-44 [PMID: 16988059]
  23. Neurology. 2011 Dec 6;77(23):2043-51 [PMID: 22116945]
  24. J Hypertens. 2013 Sep;31(9):1868-75 [PMID: 23743809]
  25. J Neurol Neurosurg Psychiatry. 2007 Dec;78(12):1298-303 [PMID: 17442763]
  26. Clin J Am Soc Nephrol. 2011 Dec;6(12):2822-8 [PMID: 22034504]
  27. Cardiol Res Pract. 2011 Jan 09;2011:306189 [PMID: 21274446]
  28. Prev Med. 2009 Feb;48(2):122-7 [PMID: 19041887]
  29. Int J Geriatr Psychiatry. 2003 Jul;18(7):609-16 [PMID: 12833305]

MeSH Term

Aged, 80 and over
Asian People
China
Cognition
Cognitive Dysfunction
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Male
Mental Status and Dementia Tests
Prospective Studies
Renal Insufficiency, Chronic
Risk Factors
Journal Article
Article has an altmetric score of 10

Word Cloud

Created with Highcharts 10.0.0cognitivedeclinekidneyparticipantsfunctionchronicdiseaseChinesefollow-upeGFRbaselineEarly-stagecorrelatedassociationoldestoldyears3KidneyevaluatedMMSEperiodobserved1mL/min/173moldest-oldpopulationBACKGROUND:suggestedrarelyexploredSUBJECTSANDMETHODS:prospectivestudyincluded284aged80olderserumcreatininelevels<150µmol/Lmediantime247870%providedvaliddatalastvisitmeasuringestimatedglomerularfiltrationrateusingMini-MentalStateExaminationannualvisitsreliabledecreasescorebasedReliableChangeIndex645equivalent90%confidenceinterval[CI]useddefinePoissonregressionmodelsbuiltanalyzeRESULTS:total1873%casesincidentadjustingpotentialconfoundersrelativeriskdeveloping40395%CI09-1381among30-59compared≥60CONCLUSION:

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