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International journal of nanomedicine
2017;12 4789-4803.

Application of nanodiagnostics in point-of-care tests for infectious diseases.

Yongzhong Wang, Li Yu, Xiaowei Kong, Leming Sun
Author Information
  1. Yongzhong Wang: Anhui Key Laboratory of Modern Biomanufacturing, School of Life Sciences, Anhui University, Hefei, Anhui, People's Republic of China.
  2. Li Yu: Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Microbiology and Parasitology, Anhui Key Laboratory of Zoonoses, Anhui Medical University, Hefei, Anhui, People's Republic of China.
  3. Xiaowei Kong: Anhui Key Laboratory of Modern Biomanufacturing, School of Life Sciences, Anhui University, Hefei, Anhui, People's Republic of China.
  4. Leming Sun: Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
PMID: 28740385 DOI: 10.2147/IJN.S137338

Abstract

Although tremendous efforts have been put into the treatment of infectious diseases to prevent epidemics and mortality, it is still one of the major health care issues that have a profound impact on humankind. Therefore, the development of specific, sensitive, accurate, rapid, low-cost, and easy-to-use diagnostic tools is still in urgent demand. Nanodiagnostics, defined as the application of nanotechnology to medical diagnostics, can offer many unique opportunities for more successful and efficient diagnosis and treatment for infectious diseases. In this review, we provide an overview of the nanodiagnostics for infectious diseases from nanoparticle-based, nanodevice-based, and point-of-care test (POCT) platforms. Most importantly, emphasis focused on the recent trends in the nanotechnology-based POCT system. The current state-of-the-art and most promising point-of-care nanodiagnostic technologies, including miniaturized diagnostic magnetic resonance platform, magnetic barcode assay system, cell phone-based polarized light microscopy platform, cell phone-based dongle platform, and paper-based POCT platform, for infectious diseases were fully examined. The limitations, challenges, and future trends of the nanodiagnostics in POCTs for infectious diseases are also discussed.

Keywords

infectious diseases nanodevices nanodiagnostics nanoparticles pathogens point-of-care test

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MeSH Term

Communicable Diseases
Humans
Magnetics
Nanomedicine
Nanoparticles
Point-of-Care Systems
Journal Article Review
Article has an altmetric score of 1

Word Cloud

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