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Annual review of virology
09 29, 2017;4 (1): 393-412.

Humanized Mouse Models for Human Immunodeficiency Virus Infection.

Matthew D Marsden, Jerome A Zack
Author Information
  1. Matthew D Marsden: Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, California 90095; email: mmarsden@ucla.edu.
  2. Jerome A Zack: Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, California 90095; email: mmarsden@ucla.edu.
PMID: 28746819 DOI: 10.1146/annurev-virology-101416-041703

Abstract

Human immunodeficiency virus (HIV) remains a significant source of morbidity and mortality worldwide. No effective vaccine is available to prevent HIV transmission, and although antiretroviral therapy can prevent disease progression, it does not cure HIV infection. Substantial effort is therefore currently directed toward basic research on HIV pathogenesis and persistence and developing methods to stop the spread of the HIV epidemic and cure those individuals already infected with HIV. Humanized mice are versatile tools for the study of HIV and its interaction with the human immune system. These models generally consist of immunodeficient mice transplanted with human cells or reconstituted with a near-complete human immune system. Here, we describe the major humanized mouse models currently in use, and some recent advances that have been made in HIV research/therapeutics using these models.

Keywords

AIDS BLT HIV humanized mice model

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Grants

  1. R01 AI070010/NIAID NIH HHS
  2. R56 AI124743/NIAID NIH HHS
  3. R01 AI124743/NIAID NIH HHS
  4. P30 AI028697/NIAID NIH HHS
  5. N01AI70010/NIAID NIH HHS
  6. R21 AI124763/NIAID NIH HHS

MeSH Term

Acquired Immunodeficiency Syndrome
Animals
Anti-HIV Agents
Disease Models, Animal
HIV Infections
HIV-1
Hematopoietic Stem Cell Transplantation
Humans
Immunologic Deficiency Syndromes
Leukocyte Transfusion
Mice
Mice, SCID

Chemicals

Anti-HIV Agents
Journal Article Review Research Support, N.I.H., Extramural
Article has an altmetric score of 59

Word Cloud

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