Oxygen Toxicity and Special Operations Forces Diving: Hidden and Dangerous.

Thijs T Wingelaar, Pieter-Jan A M van Ooij, Rob A van Hulst
Author Information
  1. Thijs T Wingelaar: Diving Medical Center, Royal Netherlands NavyDen Helder, Netherlands.
  2. Pieter-Jan A M van Ooij: Diving Medical Center, Royal Netherlands NavyDen Helder, Netherlands.
  3. Rob A van Hulst: Department of Anaesthesiology, Academic Medical CenterAmsterdam, Netherlands.

Abstract

In Special Operations Forces (SOF) closed-circuit rebreathers with 100% oxygen are commonly utilized for covert diving operations. Exposure to high partial pressures of oxygen (PO) could cause damage to the central nervous system (CNS) and pulmonary system. Longer exposure time and higher PO leads to faster development of more serious pathology. Exposure to a PO above 1.4 ATA can cause CNS toxicity, leading to a wide range of neurologic complaints including convulsions. Pulmonary oxygen toxicity develops over time when exposed to a PO above 0.5 ATA and can lead to inflammation and fibrosis of lung tissue. Oxygen can also be toxic for the ocular system and may have systemic effects on the inflammatory system. Moreover, some of the effects of oxygen toxicity are irreversible. This paper describes the pathophysiology, epidemiology, signs and symptoms, risk factors and prediction models of oxygen toxicity, and their limitations on SOF diving.

Keywords

References

  1. Undersea Hyperb Med. 1999 Spring;26(1):41-5 [PMID: 10353183]
  2. Undersea Hyperb Med. 1999 Summer;26(2):105-9 [PMID: 10372430]
  3. Undersea Hyperb Med. 2000 Spring;27(1):21-6 [PMID: 10813436]
  4. Am J Physiol Lung Cell Mol Physiol. 2000 Oct;279(4):L683-90 [PMID: 11000128]
  5. J Appl Physiol (1985). 2001 Oct;91(4):1582-7 [PMID: 11568139]
  6. Brain Res. 2001 Nov 2;917(2):253-61 [PMID: 11640911]
  7. J Appl Physiol (1985). 2002 Jan;92(1):248-56 [PMID: 11744667]
  8. Thorax. 1975 Oct;30(5):548-53 [PMID: 1198395]
  9. Ann Intern Med. 1975 Jan;82(1):40-3 [PMID: 1235760]
  10. Circ Res. 2002 Nov 29;91(11):1031-7 [PMID: 12456489]
  11. Am J Physiol. 1976 May;230(5):1425-31 [PMID: 1275087]
  12. Aviat Space Environ Med. 2003 May;74(5):537-45 [PMID: 12751583]
  13. Pediatr Res. 2003 Aug;54(2):179-84 [PMID: 12761356]
  14. J Cardiovasc Pharmacol. 2004 Jan;43(1):154-9 [PMID: 14668582]
  15. Undersea Hyperb Med. 2004 Spring;31(1):3-20 [PMID: 15233156]
  16. J Appl Physiol (1985). 2005 Jan;98(1):144-50 [PMID: 15322063]
  17. J Appl Physiol (1985). 2005 May;98(5):1653-9 [PMID: 15608093]
  18. Eur J Appl Physiol. 2005 Oct;95(2-3):191-6 [PMID: 16003537]
  19. Aviat Space Environ Med. 2005 Oct;76(10):974-7 [PMID: 16235882]
  20. Ann Neurol. 2006 Mar;59(3):467-77 [PMID: 16453316]
  21. Undersea Hyperb Med. 2005 Sep-Oct;32(5):351-61 [PMID: 16457084]
  22. Aviat Space Environ Med. 2006 May;77(5):526-32 [PMID: 16708533]
  23. J Physiol. 1899 Mar 22;24(1):19-35 [PMID: 16992479]
  24. Aviat Space Environ Med. 2006 Nov;77(11):1153-7 [PMID: 17086769]
  25. Free Radic Res. 2007 Mar;41(3):274-81 [PMID: 17364955]
  26. Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L229-38 [PMID: 17416738]
  27. J Appl Physiol (1985). 1991 Sep;71(3):878-85 [PMID: 1757324]
  28. Clin Physiol Funct Imaging. 2007 Sep;27(5):268-74 [PMID: 17697022]
  29. Eur J Neurol. 2008 Jul;15(7):746-8 [PMID: 18484987]
  30. Undersea Hyperb Med. 2008 Mar-Apr;35(2):131-43 [PMID: 18500077]
  31. Undersea Biomed Res. 1991 May;18(3):167-74 [PMID: 1853467]
  32. Eur J Appl Physiol. 2008 Nov;104(5):867-71 [PMID: 18670785]
  33. Undersea Hyperb Med. 2008 Sep-Oct;35(5):333-87 [PMID: 19024664]
  34. J Appl Physiol (1985). 2009 Jan;106(1):276-83 [PMID: 19036887]
  35. Undersea Hyperb Med. 2008 Nov-Dec;35(6):417-26 [PMID: 19175197]
  36. J Sports Sci. 2009 Apr;27(6):641-9 [PMID: 19296363]
  37. Eur J Appl Physiol Occup Physiol. 1991;62(2):122-9 [PMID: 2022200]
  38. Anesth Analg. 1990 Feb;70(2):195-207 [PMID: 2105672]
  39. Clin Physiol Funct Imaging. 2011 Sep;31(5):405-10 [PMID: 21771262]
  40. Aviat Space Environ Med. 2011 Oct;82(10):946-50 [PMID: 21961398]
  41. Undersea Biomed Res. 1990 Sep;17(5):413-28 [PMID: 2219550]
  42. Antioxid Redox Signal. 2013 Oct 1;19(10):1110-20 [PMID: 22530599]
  43. Undersea Hyperb Med. 2012 May-Jun;39(3):699-707 [PMID: 22670550]
  44. Undersea Hyperb Med. 2013 Mar-Apr;40(2):155-63 [PMID: 23682547]
  45. Respir Physiol Neurobiol. 2013 Oct 1;189(1):117-28 [PMID: 23886638]
  46. AANA J. 2013 Jun;81(3):205-8 [PMID: 23923671]
  47. Clin Physiol Funct Imaging. 2014 May;34(3):199-208 [PMID: 24034178]
  48. Diving Hyperb Med. 2013 Sep;43(3):148-56 [PMID: 24122190]
  49. Respir Physiol Neurobiol. 2014 Jul 1;198:20-4 [PMID: 24703972]
  50. Eur Respir J. 2014 Jul;44(1):188-97 [PMID: 24743964]
  51. Brain Res. 2014 Jul 29;1574:77-83 [PMID: 24928619]
  52. Biochem Med (Zagreb). 2014;24(2):235-47 [PMID: 24969917]
  53. Mil Med. 2014 Aug;179(8):926-32 [PMID: 25102538]
  54. Undersea Hyperb Med. 2014 Jul-Aug;41(4):331-5 [PMID: 25109086]
  55. Clin Exp Optom. 2015 Mar;98(2):122-5 [PMID: 25308346]
  56. Trends Mol Med. 2015 Oct;21(10):633-644 [PMID: 26432020]
  57. Aerosp Med Hum Perform. 2016 May;87(5):477-86 [PMID: 27099087]
  58. Respir Physiol. 1989 Mar;75(3):255-65 [PMID: 2717815]
  59. J Allergy Clin Immunol. 2016 Oct;138(4):970-976 [PMID: 27590400]
  60. Eur Respir Rev. 2016 Dec;25(142):496-505 [PMID: 27903670]
  61. Undersea Hyperb Med. 2016 Sept-Oct;43(6):649-657 [PMID: 28768392]
  62. Clin Chest Med. 1988 Mar;9(1):141-52 [PMID: 3280227]
  63. Toxicol Appl Pharmacol. 1988 Apr;93(2):298-311 [PMID: 3358265]
  64. J Appl Physiol (1985). 1987 Feb;62(2):533-8 [PMID: 3558213]
  65. Aviat Space Environ Med. 1987 Jul;58(7):658-67 [PMID: 3619841]
  66. Undersea Biomed Res. 1987 Jul;14(4):301-10 [PMID: 3629742]
  67. J Appl Physiol (1985). 1987 Sep;63(3):1130-5 [PMID: 3654459]
  68. Undersea Biomed Res. 1987 Nov;14(6):477-83 [PMID: 3686742]
  69. Undersea Biomed Res. 1986 Mar;13(1):91-8 [PMID: 3705251]
  70. J Appl Physiol (1985). 1986 Aug;61(2):565-74 [PMID: 3745047]
  71. Eur J Appl Physiol Occup Physiol. 1985;54(1):71-8 [PMID: 4018059]
  72. Am J Pathol. 1974 Jul;76(1):175-8 [PMID: 4210278]
  73. Anesthesiology. 1972 Aug;37(2):210-41 [PMID: 4559456]
  74. Chest. 1972 Aug;62(2):162-9 [PMID: 5050222]
  75. J Appl Physiol. 1971 Aug;31(2):235-42 [PMID: 5558246]
  76. Int Anesthesiol Clin. 1981 Fall;19(3):179-99 [PMID: 6169647]
  77. Undersea Biomed Res. 1978 Mar;5(1):71-85 [PMID: 636076]
  78. Undersea Biomed Res. 1983 Dec;10(4):331-42 [PMID: 6675229]
  79. Br J Ophthalmol. 1984 Feb;68(2):113-7 [PMID: 6691953]
  80. Respir Physiol. 1978 Sep;34(3):307-18 [PMID: 705086]
  81. Respiration. 1982;43(6):408-13 [PMID: 7178668]
  82. J Appl Physiol Respir Environ Exerc Physiol. 1978 Nov;45(5):699-704 [PMID: 730565]
  83. Surv Ophthalmol. 1995 Mar-Apr;39(5):347-66 [PMID: 7604359]
  84. Toxicol Appl Pharmacol. 1995 May;132(1):19-26 [PMID: 7747281]
  85. Undersea Hyperb Med. 1995 Dec;22(4):339-46 [PMID: 8574121]
  86. Brain Res. 1995 Oct 23;696(1-2):250-3 [PMID: 8574677]
  87. J Appl Physiol Respir Environ Exerc Physiol. 1977 Apr;42(4):593-9 [PMID: 863821]
  88. Undersea Hyperb Med. 1996 Jun;23(2):91-8 [PMID: 8840477]
  89. Undersea Hyperb Med. 1996 Sep;23(3):157-65 [PMID: 8931283]
  90. Brain Res. 1997 Jun 27;761(1):146-50 [PMID: 9247077]
  91. Brain Res. 1998 Apr 27;791(1-2):75-82 [PMID: 9593832]
  92. J Appl Physiol (1985). 1999 Jan;86(1):243-59 [PMID: 9887137]
  93. Pediatr Res. 1999 Jan;45(1):8-13 [PMID: 9890602]

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