Co-circulation of Araraquara and Juquitiba Hantavirus in Brazilian Cerrado.
Alexandro Guterres, Renata Carvalho de Oliveira, Jorlan Fernandes, Renata Malachini Maia, Bernardo Rodrigues Teixeira, Flávio César Gomes Oliveira, Cibele Rodrigues Bonvicino, Paulo Sergio D'Andrea, Carlos Guerra Schrago, Elba Regina Sampaio de Lemos
Author Information
Alexandro Guterres: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Helio e Peggy Pereira - 1° Pav. Sala B115, Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil. guterres@ioc.fiocruz.br.
Renata Carvalho de Oliveira: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Helio e Peggy Pereira - 1° Pav. Sala B115, Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil.
Jorlan Fernandes: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Helio e Peggy Pereira - 1° Pav. Sala B115, Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil.
Renata Malachini Maia: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Helio e Peggy Pereira - 1° Pav. Sala B115, Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil.
Bernardo Rodrigues Teixeira: Laboratorio de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Flávio César Gomes Oliveira: Centro Tecnológico de Engenharia LTDA, Goiânia, GO, Brazil.
Cibele Rodrigues Bonvicino: Laboratorio de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Paulo Sergio D'Andrea: Laboratorio de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Carlos Guerra Schrago: Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Elba Regina Sampaio de Lemos: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Helio e Peggy Pereira - 1° Pav. Sala B115, Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil. elemos@ioc.fiocruz.br.
Hantavirus cardiopulmonary syndrome is an emerging serious disease in the Americas, transmitted from wild rodents to humans through inhalation of aerosol containing virus. Herein, we characterized two distinct hantaviruses circulating in rodent species form Central Plateau, Midwestern region of Brazil in the Cerrado (savanna-like) biome, an area characterized by small trees and grasses adapted to climates with long dry periods. In this study, we identified the co-circulation of the Araraquara virus and a possible new lineage of the Juquitiba virus (JUQV) in Oligoryzomys nigripes. The implications of co-circulation are still unknown, but it can be the key for increasing viral diversity or emergence of new species through spillover or host switching events leading to co-infection and consequently recombination or reassortment between different virus species. Phylogenetic analyses based on the complete S segment indicated that, alongside with Oligoryzomys mattogrossae rodents, O. nigripes species could also have a whole as JUQV reservoir in the Cerrado biome. Although these rodents' species are common in the Cerrado biome, they are not abundant demonstrating how complex and different hantavirus enzootic cycles can be in this particular biome.
