Instrumentation for electrochemical performance characterization of neural electrodes.
Michael P Marsh, James N Kruchowski, Seth A Hara, Malcom B McIntosh, Renae M Forsman, Terry L Reed, Christopher Kimble, Kendall H Lee, Kevin E Bennet, Jonathan R Tomshine
Author Information
Michael P Marsh: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
James N Kruchowski: Division of Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.
Seth A Hara: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA. ORCID
Malcom B McIntosh: Division of Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.
Renae M Forsman: Division of Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.
Terry L Reed: Division of Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.
Christopher Kimble: Division of Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA.
Kendall H Lee: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
Kevin E Bennet: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA. ORCID
Jonathan R Tomshine: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
In an effort to determine the chronic stability, sensitivity, and thus the potential viability of various neurochemical recording electrode designs and compositions, we have developed a custom device called the Voltammetry Instrument for Neurochemical Applications (VINA). Here, we describe the design of the VINA and initial testing of its functionality for prototype neurochemical sensing electrodes. The VINA consists of multiple electrode fixtures, a flowing electrolyte bath, associated reservoirs, peristaltic pump, voltage waveform generator, data acquisition hardware, and system software written in National Instrument's LabVIEW. The operation of VINA was demonstrated on a set of boron-doped diamond neurochemical recording electrodes, which were subjected to an applied waveform for a period of eighteen days. Each electrode's cyclic voltammograms (CVs) were recorded, and sensitivity calibration to dopamine (DA) was performed. Results showed an initial decline with subsequent stabilization in the CV current measured during the voltammetric sweep, corresponding closely with changes in electrode sensitivity to DA. The VINA has demonstrated itself as a useful tool for the characterization of electrode stability and chronic electrochemical performance.
References
Brain Res. 1973 May 30;55(1):209-13
[PMID: 4145914]
Nature. 1999 Mar 4;398(6722):67-9
[PMID: 10078530]
