Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea.
Min Chul Kim, Yong Sook Kim, Wan Seok Kang, Ki Hong Lee, Meeyoung Cho, Moon Hwa Hong, Kyung Seob Lim, Myung Ho Jeong, Youngkeun Ahn
Author Information
Min Chul Kim: Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea. ORCID
Yong Sook Kim: Biomedical Research Institute, Chonnam National University Hospital, Gwangju, Korea. ORCID
Wan Seok Kang: Biomedical Research Institute, Chonnam National University Hospital, Gwangju, Korea. ORCID
Ki Hong Lee: Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea. ORCID
Meeyoung Cho: Cell Regeneration Research Center, Chonnam National University Hospital, Gwangju, Korea. ORCID
Moon Hwa Hong: Cell Regeneration Research Center, Chonnam National University Hospital, Gwangju, Korea. ORCID
Kyung Seob Lim: Biomedical Research Institute, Chonnam National University Hospital, Gwangju, Korea. ORCID
Myung Ho Jeong: Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea. ORCID
Youngkeun Ahn: Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea. ORCID
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA® XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future.
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Animals
Disease Models, Animal
Drug Administration Routes
Echocardiography
Heart
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Myocardial Infarction
Republic of Korea
Swine
Ventricular Function, Left
