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Scientific reports
09 11, 2017;7 (1): 11238.

A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure.

Naghmeh Sattarahmady, Amid Rahi, Hossein Heli
Author Information
  1. Naghmeh Sattarahmady: Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  2. Amid Rahi: Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  3. Hossein Heli: Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. heli@sums.ac.ir.
PMID: 28894225 DOI: 10.1038/s41598-017-11680-5

Abstract

A green electrodeposition method was firstly employed for the synthesis of round hairbrush-like gold nanostructure in the presence of cadaverine as a size and shape directing additive. The nanostructure which comprised of arrays of nanospindles was then applied as a transducer to fabricate a signal-on built in-marker electrochemical aptasensor for the detection of human prostate-specific antigen (PSA). The aptasensor detected PSA with a linear concentration range of 0.125 to 128 ng mL and a limit of detection of 50 pg mL. The aptasensor was then successfully applied to detect PSA in the blood serum samples of healthy and patient persons.

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MeSH Term

Blood Chemical Analysis
Diagnostic Tests, Routine
Gold
Humans
Male
Nanostructures
Prostate-Specific Antigen
Prostatic Neoplasms

Chemicals

Gold
Prostate-Specific Antigen
Evaluation Study Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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