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Oct 11, 2017;117 (19): 12415-12474.

Natural Products as Platforms To Overcome Antibiotic Resistance.

Sean E Rossiter, Madison H Fletcher, William M Wuest
Author Information
  1. Sean E Rossiter: Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  2. Madison H Fletcher: Department of Chemistry, Temple University , 1901 North 13th Street, Philadelphia, Pennsylvania 19122, United States.
  3. William M Wuest: Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States. ORCID
PMID: 28953368 DOI: 10.1021/acs.chemrev.7b00283

Abstract

Natural products have served as powerful therapeutics against pathogenic bacteria since the golden age of antibiotics of the mid-20th century. However, the increasing frequency of antibiotic-resistant infections clearly demonstrates that new antibiotics are critical for modern medicine. Because combinatorial approaches have not yielded effective drugs, we propose that the development of new antibiotics around proven natural scaffolds is the best short-term solution to the rising crisis of antibiotic resistance. We analyze herein synthetic approaches aiming to reengineer natural products into potent antibiotics. Furthermore, we discuss approaches in modulating quorum sensing and biofilm formation as a nonlethal method, as well as narrow-spectrum pathogen-specific antibiotics, which are of interest given new insights into the implications of disrupting the microbiome.

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Grants

  1. P41 GM103311/NIGMS NIH HHS
  2. R35 GM119426/NIGMS NIH HHS

MeSH Term

Anti-Bacterial Agents
Bacteria
Biofilms
Biological Products
Drug Resistance, Microbial
Microbial Sensitivity Tests

Chemicals

Anti-Bacterial Agents
Biological Products
Journal Article Review
Article has an altmetric score of 34

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