Analysis of the conformations of the HIV-1 protease from a large crystallographic data set.

Luigi Leonardo Palese
Author Information
  1. Luigi Leonardo Palese: University of Bari "Aldo Moro", Department of Basic Medical Sciences, Neurosciences and Sense Organs (SMBNOS), Bari 70124, Italy.

Abstract

The HIV-1 protease performs essential roles in viral maturation by processing specific cleavage sites in the Gag and Gag-Pol precursor polyproteins to release their mature forms. Here the analysis of a large HIV-1 protease data set (containing 552 dimer structures) are reported. These data are related to article entitled "Conformations of the HIV-1 protease: a crystal structure data set analysis" (Palese, 2017) [1].

References

  1. Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [PMID: 10592235]
  2. Nat Med. 2000 Nov;6(11):1290-2 [PMID: 11062545]
  3. Nucleic Acids Res. 2003 Jan 1;31(1):298-303 [PMID: 12520007]
  4. Nat Struct Biol. 2003 Dec;10(12):980 [PMID: 14634627]
  5. AIDS. 2006 Mar 21;20(5):643-51 [PMID: 16514293]
  6. J Infect Dis. 2006 Sep 15;194 Suppl 1:S51-8 [PMID: 16921473]
  7. Biochem Biophys Res Commun. 2011 Jan 7;404(1):438-42 [PMID: 21138729]
  8. Bioinformatics. 2011 Jun 1;27(11):1575-7 [PMID: 21471012]
  9. Biochim Biophys Acta. 2013 Dec;1834(12):2486-93 [PMID: 24016775]
  10. Biophys Chem. 2015 Jan;196:1-9 [PMID: 25237718]
  11. J Phys Chem B. 2015 Dec 24;119(51):15568-73 [PMID: 26619349]
  12. Nucleic Acids Res. 2017 Jan 4;45(D1):D271-D281 [PMID: 27794042]
  13. Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt A):1416-1422 [PMID: 28846854]
  14. Comput Biol Chem. 2018 Apr;73:57-64 [PMID: 29428276]
  15. J Mol Graph. 1996 Feb;14(1):33-8, 27-8 [PMID: 8744570]

Word Cloud

Created with Highcharts 10.0.0HIV-1dataproteasesetlargeperformsessentialrolesviralmaturationprocessingspecificcleavagesitesGagGag-Polprecursorpolyproteinsreleasematureformsanalysiscontaining552dimerstructuresreportedrelatedarticleentitled"Conformationsprotease:crystalstructureanalysis"Palese2017[1]Analysisconformationscrystallographic

Similar Articles

Cited By