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Cell death discovery
2017;3 17071.

Zinc-finger proteins in health and disease.

Matteo Cassandri, Artem Smirnov, Flavia Novelli, Consuelo Pitolli, Massimiliano Agostini, Michal Malewicz, Gerry Melino, Giuseppe Raschellà
Author Information
  1. Matteo Cassandri: Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome 00133, Italy.
  2. Artem Smirnov: Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome 00133, Italy.
  3. Flavia Novelli: Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome 00133, Italy.
  4. Consuelo Pitolli: Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome 00133, Italy.
  5. Massimiliano Agostini: Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome 00133, Italy.
  6. Michal Malewicz: Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK.
  7. Gerry Melino: Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome 00133, Italy.
  8. Giuseppe Raschellà: ENEA Research Center Casaccia, Laboratory of Biosafety and Risk Assessment, Via Anguillarese, Rome, Italy.
PMID: 29152378 DOI: 10.1038/cddiscovery.2017.71

Abstract

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of several cellular processes. In fact, ZNFs are implicated in transcriptional regulation, ubiquitin-mediated protein degradation, signal transduction, actin targeting, DNA repair, cell migration, and numerous other processes. The aim of this review is to provide a comprehensive summary of the current state of knowledge of this class of proteins. Firstly, we describe the actual classification of ZNFs, their structure and functions. Secondly, we focus on the biological role of ZNFs in the development of organisms under normal physiological and pathological conditions.

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Journal Article Review
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Word Cloud

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