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BJPsych open
Nov, 2017;3 (6): 265-273.

Individual differences in schizophrenia.

Edmund T Rolls, Wenlian Lu, Lin Wan, Hao Yan, Chuanyue Wang, Fude Yang, Yunlong Tan, Lingjiang Li, Chinese Schizophrenia Collaboration Group, Hao Yu, Peter F Liddle, Lena Palaniyappan, Dai Zhang, Weihua Yue, Jianfeng Feng
Author Information
  1. Edmund T Rolls: , MA, DPhil, DSc, Department of Computer Science, University of Warwick, Coventry, UK; Oxford Centre for Computational Neuroscience, Oxford, UK.
  2. Wenlian Lu: PhD, Centre for Computational Systems Biology, Fudan University, Shanghai, PR China.
  3. Lin Wan: , PhD, National Center for Mathematics and Interdisciplinary Sciences, The Key Laboratory of Systems and Control, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, PR China.
  4. Hao Yan: , MD, Institute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China.
  5. Chuanyue Wang: , MD, Beijing Anding Hospital, Capital Medical University, Beijing, PR China.
  6. Fude Yang: , M.M., Beijing HuiLongGuan Hospital, Peking University, Beijing, PR China.
  7. Yunlong Tan: , Beijing HuiLongGuan Hospital, Peking University, Beijing, PR China.
  8. Lingjiang Li: , MD, Institute of Mental Health, The Second Xiangya Hospital of Central South University, Changsha, PR China.
  9. Hao Yu: , PhD, Institute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China.
  10. Peter F Liddle: , MBBS, MRCPsych, PhD, Centre for Translational Neuroimaging, Institute of Mental Health, Division of Psychiatry & Applied Psychology, University of Nottingham, Nottingham, UK; Sir Peter Mansfield MR Centre, University of Nottingham, Nottingham, UK.
  11. Lena Palaniyappan: , MBBS, PhD, Department of Psychiatry, University of Western Ontario, London, Ontario, Canada; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; Robarts & Lawson Health Research Institutes, London, Ontario, Canada.
  12. Dai Zhang: , MD, Institute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China; Peking-Tsinghua Joint Center for Life Sciences/PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
  13. Weihua Yue: , MD, Institute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China.
  14. Jianfeng Feng: , PhD, Department of Computer Science, University of Warwick, Coventry, UK.
PMID: 29163982 DOI: 10.1192/bjpo.bp.117.005058

Abstract

BACKGROUND: Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia.
AIMS: To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how first-episode patients (FEP) may differ from multiple episode patients (MEP).
METHOD: These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks.
RESULTS: The seven Negative Symptoms were correlated with each other and with P2 (conceptual disorganisation), G13 (disturbance of volition), and G7 (motor retardation). The main difference between individuals was in the cluster of seven negative symptoms, which had a continuous unimodal distribution. Medication decreased the PANSS scores for all the symptoms, which were similar in the FEP and MEP groups.
CONCLUSIONS: The negative symptoms are a major source of individual differences, and there are potential implications for treatment.
DECLARATION OF INTERESTS: L.P. received speaker fees from Otsuka Canada and educational grant from Janssen Canada in 2017.
COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

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Grants

  1. MR/K020803/1/Medical Research Council
Journal Article
Article has an altmetric score of 5

Word Cloud

Created with Highcharts 10.0.0schizophreniaindividualsdifferencesFEPMEPsymptomssubtypesadvanceunderstandingtreatmentpatientsNegativePANSSsevennegativeCanada2017BACKGROUND:WhetherdistinctimportantissueAIMS:understandtreataimwhetherdiscretefirst-episodemaydiffermultipleepisodeMETHOD:issuesanalysed6871880usingPositiveSyndromeScaleantipsychoticmedication6weeksRESULTS:SymptomscorrelatedP2conceptualdisorganisationG13disturbancevolitionG7motorretardationmaindifferenceclustercontinuousunimodaldistributionMedicationdecreasedscoressimilargroupsCONCLUSIONS:majorsourceindividualpotentialimplicationsDECLARATIONOFINTERESTS:LPreceivedspeakerfeesOtsukaeducationalgrantJanssenCOPYRIGHTANDUSAGE:©RoyalCollegePsychiatristsopenaccessarticledistributedtermsCreativeCommonsNon-CommercialDerivativesCCBY-NC-NDlicenseIndividual

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