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Cell death & disease
11 30, 2017;8 (11): e3174.

H19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p.

Chun-Xiao Li, Hua-Guo Li, Lin-Ting Huang, Yu-Wei Kong, Fu-Ying Chen, Jian-Yin Liang, Hong Yu, Zhi-Rong Yao
Author Information
  1. Chun-Xiao Li: Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  2. Hua-Guo Li: Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  3. Lin-Ting Huang: Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  4. Yu-Wei Kong: Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  5. Fu-Ying Chen: Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  6. Jian-Yin Liang: Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  7. Hong Yu: Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  8. Zhi-Rong Yao: Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
PMID: 29192645 DOI: 10.1038/cddis.2017.516

Abstract

Aberrant differentiation of keratinocytes has been demonstrated to be associated with a number of skin diseases. A growing number of studies have showed that long noncoding RNAs (lncRNAs) have an important part in gene regulation, however, the role of lncRNAs in keratinocyte differentiation remains to be largely unknown. In the present study, we demonstrated that lncRNA-H19 act as an endogenous 'sponge', which binds directly to miR-130b-3p and therefore inhibits its activity on Dsg1. MiR-130b-3p was illustrated to inhibit keratinocyte differentiation by targeting Dsg1. H19 regulates Dsg1 expression and the consequent keratinocyte differentiation through miR-130b-3p. Our study casts light on a novel regulatory model of keratinocyte differentiation, which may provide new therapeutic targets of skin diseases.

References

  1. J Invest Dermatol. 2016 Jan;136(1):182-91 [PMID: 26763438]
  2. Oncogene. 2013 Jul 4;32(27):3286-95 [PMID: 22847613]
  3. Nat Commun. 2015 Apr 10;6:6779 [PMID: 25858075]
  4. PLoS Genet. 2014 Jul 24;10(7):e1004467 [PMID: 25057983]
  5. J Cell Biol. 2009 Jun 29;185(7):1243-58 [PMID: 19546243]
  6. Circ Res. 2014 Apr 25;114(9):1377-88 [PMID: 24557880]
  7. Cancer Res. 2014 Dec 1;74(23):6890-902 [PMID: 25277524]
  8. J Invest Dermatol. 2016 Sep;136(9):1840-7 [PMID: 27255610]
  9. Nat Commun. 2015 Jul 03;6:7652 [PMID: 26138368]
  10. PLoS One. 2016 Mar 08;11(3):e0150418 [PMID: 26953888]
  11. EMBO J. 2013 Aug 14;32(16):2248-63 [PMID: 23860128]
  12. J Clin Invest. 2013 Apr;123(4):1556-70 [PMID: 23524970]
  13. Cell. 2013 Apr 25;153(3):516-9 [PMID: 23622238]
  14. J Cell Biol. 2012 Oct 15;199(2):347-63 [PMID: 23071155]
  15. Science. 2014 Apr 18;344(6181):310-3 [PMID: 24744378]
  16. Genome Biol. 2015 Jan 30;16:24 [PMID: 25723451]
  17. Arthritis Rheumatol. 2016 Sep;68(9):2232-43 [PMID: 27111096]
  18. Nat Commun. 2016 Mar 22;7:10993 [PMID: 27001906]
  19. J Invest Dermatol. 2011 Jan;131(1):20-9 [PMID: 20827281]
  20. Genes Dev. 2012 Feb 15;26(4):338-43 [PMID: 22302877]
  21. Cell. 2011 Aug 5;146(3):353-8 [PMID: 21802130]
  22. Cell Stem Cell. 2010 Dec 3;7(6):694-707 [PMID: 21112564]
  23. J Cell Biol. 2008 Jan 28;180(2):273-84 [PMID: 18209104]
  24. Nat Genet. 2006 Mar;38(3):356-62 [PMID: 16462742]
  25. Cell. 2011 Oct 14;147(2):358-69 [PMID: 22000014]
  26. Lancet. 2015 Sep 5;386(9997):983-94 [PMID: 26025581]
  27. PLoS One. 2015 Aug 27;10(8):e0136049 [PMID: 26313654]
  28. Cell Rep. 2015 May 12;11(6):967-976 [PMID: 25937287]
  29. Cell Death Differ. 2015 Jan;22(1):12-21 [PMID: 25168241]
  30. Nature. 2013 Jan 10;493(7431):231-5 [PMID: 23201690]
  31. Development. 2012 Apr;139(8):1405-16 [PMID: 22434867]
  32. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1133-8 [PMID: 22228303]
  33. Nat Rev Mol Cell Biol. 2009 Mar;10(3):207-17 [PMID: 19209183]
  34. Cell Death Differ. 2013 Jun;20(6):800-11 [PMID: 23429262]
  35. J Invest Dermatol. 2016 Mar;136(3):603-9 [PMID: 27015450]
  36. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2876-81 [PMID: 23382218]
  37. J Clin Invest. 2013 Apr;123(4):1419-22 [PMID: 23524961]

MeSH Term

Cell Differentiation
Child
Desmoglein 1
Gene Expression Regulation
Genes, Tumor Suppressor
Humans
Keratinocytes
MicroRNAs
RNA, Long Noncoding
Transfection

Chemicals

DSG1 protein, human
Desmoglein 1
H19 long non-coding RNA
MIRN130 microRNA, human
MicroRNAs
RNA, Long Noncoding
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 3

Word Cloud

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