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Diabetes & metabolism journal
Dec, 2017;41 (6): 474-485.

Beneficial Effects of Aerobic Exercise Training Combined with Rosiglitazone on Glucose Metabolism in Otsuka Long Evans Tokushima Fatty Rats.

Shan Ji Piao, So Hun Kim, Young Ju Suh, Seong Bin Hong, Seong Hee Ahn, Da Hae Seo, In Sun Park, Moonsuk Nam
Author Information
  1. Shan Ji Piao: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
  2. So Hun Kim: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
  3. Young Ju Suh: Department of Biomedical Sciences, Inha University School of Medicine, Incheon, Korea.
  4. Seong Bin Hong: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
  5. Seong Hee Ahn: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
  6. Da Hae Seo: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
  7. In Sun Park: Department of Anatomy, Inha University School of Medicine, Incheon, Korea. sunpark@inha.ac.kr. ORCID
  8. Moonsuk Nam: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea. namms@inha.ac.kr. ORCID
PMID: 29199408 DOI: 10.4093/dmj.2017.41.6.474

Abstract

BACKGROUND: Regular aerobic exercise is essential for the prevention and management of type 2 diabetes mellitus and may be particularly beneficial for those treated with thiazolidinediones, since it may prevent associated weight gain. This study aimed to evaluate the effect of combined exercise and rosiglitazone treatment on body composition and glucose metabolism in obese diabetes-prone animals.
METHODS: We analyzed metabolic parameters, body composition, and islet profiles in Otsuka Long Evans Tokushima Fatty rats after 28 weeks of aerobic exercise, rosiglitazone treatment, and combined exercise and rosiglitazone treatment.
RESULTS: Combined exercise with rosiglitazone showed significantly less increase in weight and epididymal fat compared to rosiglitazone treatment. Aerobic exercise alone and combined rosiglitazone and exercise treatment led to similar retention of lean body mass. All experimental groups showed a decrease in fasting glucose. However, the combined exercise and rosiglitazone therapy group showed prominent improvement in glucose tolerance compared to the other groups. Rescue of islet destruction was observed in all experimental groups, but was most prominent in the combined therapy group.
CONCLUSION: Regular aerobic exercise combined with rosiglitazone treatment can compensate for the adverse effect of rosiglitazone treatment and has benefit for islet preservation.

Keywords

Beta-cell Body composition Diabetes Exercise Rats, inbred OLETF Rosiglitazone

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Journal Article

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