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Physiological reports
Dec, 2017;5 (23):

The impact of acute bouts of interval and continuous walking on energy-intake and appetite regulation in subjects with type 2 diabetes.

Ida A Müller, Anne-Sophie Wedell-Neergaard, Thomas P J Solomon, Kristian Karstoft
Author Information
  1. Ida A Müller: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  2. Anne-Sophie Wedell-Neergaard: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  3. Thomas P J Solomon: School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
  4. Kristian Karstoft: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. ORCID
PMID: 29208688 DOI: 10.14814/phy2.13524

Abstract

In healthy subjects, it has been suggested that exercise may acutely suppress energy-intake and appetite, with peak intensity being an important determinant for this effect. In subjects with type 2 diabetes (T2D), the effect of exercise on appetite-related variables is, however, virtually unknown. We aimed to assess the effects of two exercise interventions, differing with regards to peak intensity, on energy-intake, satiety and appetite-related hormones in subjects with T2D. Thirteen subjects with T2D completed three 60-min interventions with continuous measurement of oxygen consumption in a randomized and counterbalanced order: (1) Control, (2) Continuous walking (CW; intended 73% of VOpeak), (3) Interval-walking (IW; repeated cycles of 3 min slow [54% of VOpeak] and 3 min fast walking [89% of VOpeak]). Forty-five minutes after completion of the intervention, a 3-h liquid mixed meal tolerance test (MMTT, 450 kcal) with regular satiety assessments and blood samples for appetite-related hormones commenced. An ad libitum meal was served after the MMTT, with subsequent calculation of energy-intake. Moreover, free-living diet records were completed for the following ~32 h. Exercise interventions were well-matched for mean oxygen consumption (CW = 77 ± 2% of VOpeak; IW = 76 ± 1% of VOpeak,  > 0.05). No differences in appetite-related hormones or energy-intake were found ( > 0.05 for all comparisons). IW increased fullness compared to Control shortly after the intervention ( < 0.05) and tended to reduce hunger 2 h into the MMTT compared to CW and Control ( < 0.10). In conclusion, a single exercise session does not affect energy-intake during the following ~4-36 h in subjects with T2D. However, satiety may be affected up to ~3 h after the exercise session, dependent on peak intensity.

Keywords

Appetite exercise gastric emptying gut hormones type 2 diabetes

References

  1. Appetite. 2013 Feb;61(1):45-51 [PMID: 23137828]
  2. Nutrients. 2017 Apr 05;9(4): [PMID: 28379172]
  3. Eur J Clin Nutr. 1994 Oct;48(10):715-24 [PMID: 7835326]
  4. Med Sci Sports Exerc. 1982;14(5):377-81 [PMID: 7154893]
  5. Aliment Pharmacol Ther. 1999 May;13(5):609-20 [PMID: 10233184]
  6. Aliment Pharmacol Ther. 2011 Apr;33(8):880-94 [PMID: 21342212]
  7. J Clin Endocrinol Metab. 2009 Nov;94(11):4258-66 [PMID: 19808853]
  8. Lancet Diabetes Endocrinol. 2016 Nov;4(11):913-921 [PMID: 27595918]
  9. Scand J Med Sci Sports. 2015 Dec;25 Suppl 3:1-72 [PMID: 26606383]
  10. J Appl Physiol (1985). 2013 Sep 1;115(5):618-25 [PMID: 23788577]
  11. Diabetes Care. 2016 Jan;39 Suppl 1:S13-22 [PMID: 26696675]
  12. Ann Agric Environ Med. 2013;20(4):787-93 [PMID: 24364454]
  13. J Clin Endocrinol Metab. 2014 Sep;99(9):3334-42 [PMID: 24905068]
  14. Am J Physiol Endocrinol Metab. 2014 Jan 15;306(2):E225-31 [PMID: 24302008]
  15. Methods Enzymol. 2012;514:113-26 [PMID: 22975050]
  16. Sports Med. 2014 Mar;44(3):387-403 [PMID: 24174308]
  17. Appl Physiol Nutr Metab. 2013 Dec;38(12):1236-44 [PMID: 24195624]
  18. Metabolism. 2016 Sep;65(9):1316-25 [PMID: 27506739]
  19. Int J Obes Relat Metab Disord. 1999 Dec;23(12):1282-7 [PMID: 10643685]
  20. Int J Obes (Lond). 2014 Mar;38(3):417-22 [PMID: 23835594]
  21. Sports Med. 2015 May;45(5):659-78 [PMID: 25398225]
  22. J Endocrinol. 2009 Apr;201(1):151-9 [PMID: 19158129]
  23. Physiol Rep. 2017 Dec;5(23): [PMID: 29208688]
  24. Br J Nutr. 2001 Apr;85(4):415-30 [PMID: 11348556]
  25. Appetite. 2016 Mar 1;98:80-8 [PMID: 26721721]
  26. Diabetes Care. 2004 Mar;27(3):663-9 [PMID: 14988282]
  27. Diabetes Care. 2013 Feb;36(2):228-36 [PMID: 23002086]
  28. Int J Obes (Lond). 2014 May;38(5):750 [PMID: 24002323]
  29. Br J Sports Med. 2012 Apr;46(5):315-22 [PMID: 21596715]
  30. Int J Obes Relat Metab Disord. 2000 Jan;24(1):38-48 [PMID: 10702749]
  31. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003817 [PMID: 17054187]
  32. J Endocrinol. 2009 Dec;203(3):357-64 [PMID: 19737911]
  33. Diabetes. 2005 May;54(5):1371-8 [PMID: 15855322]
  34. Med Sci Sports Exerc. 2016 Feb;48(2):182-9 [PMID: 26285022]
  35. Diabetes Care. 2014 Jan;37 Suppl 1:S14-80 [PMID: 24357209]
  36. J Chronic Dis. 1978;31(12):741-55 [PMID: 748370]
  37. Am J Clin Nutr. 2004 Nov;80(5):1230-6 [PMID: 15531670]
  38. Int J Obes (Lond). 2008 Sep;32(9):1337-47 [PMID: 18607378]
  39. Ann Intern Med. 2000 Jul 18;133(2):92-103 [PMID: 10896648]

MeSH Term

Aged
Appetite
Diabetes Mellitus, Type 2
Energy Intake
Exercise Therapy
Female
Gastric Emptying
Gastrointestinal Hormones
Humans
Male
Middle Aged
Oxygen Consumption
Walking

Chemicals

Gastrointestinal Hormones
Journal Article Randomized Controlled Trial
Article has an altmetric score of 4

Word Cloud

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