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CPT: pharmacometrics & systems pharmacology
02, 2018;7 (2): 69-81.

Translational Systems Pharmacology Studies in Pregnant Women.

Sara K Quinney, Rakesh Gullapelli, David M Haas
Author Information
  1. Sara K Quinney: Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  2. Rakesh Gullapelli: School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, USA.
  3. David M Haas: Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
PMID: 29239132 DOI: 10.1002/psp4.12269

Abstract

Pregnancy involves rapid physiological adaptation and complex interplay between mother and fetus. New analytic technologies provide large amounts of genomic, proteomic, and metabolomics data. The integration of these data through bioinformatics, statistical, and systems pharmacology techniques can improve our understanding of the mechanisms of normal maternal physiologic changes and fetal development. New insights into the mechanisms of pregnancy-related disorders, such as preterm birth (PTB), may lead to the development of new therapeutic interventions and novel biomarkers.

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Grants

  1. K23 HD071134/NICHD NIH HHS

MeSH Term

Computational Biology
Female
Genomics
Humans
Metabolomics
Pharmacology
Pregnancy
Pregnancy Complications
Proteomics
Translational Research, Biomedical
Journal Article Research Support, N.I.H., Extramural Review
Article has an altmetric score of 1

Word Cloud

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