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Child development
01, 2019;90 (1): e96-e113.

Differential Associations of Distinct Forms of Childhood Adversity With Neurobehavioral Measures of Reward Processing: A Developmental Pathway to Depression.

Meg J Dennison, Maya L Rosen, Kelly A Sambrook, Jessica L Jenness, Margaret A Sheridan, Katie A McLaughlin
Author Information
  1. Meg J Dennison: University of Washington. ORCID
  2. Maya L Rosen: University of Washington.
  3. Kelly A Sambrook: University of Washington.
  4. Jessica L Jenness: University of Washington.
  5. Margaret A Sheridan: University of North Carolina, Chapel Hill.
  6. Katie A McLaughlin: University of Washington.
PMID: 29266223 DOI: 10.1111/cdev.13011

Abstract

Childhood adversity is associated with altered reward processing, but little is known about whether this varies across distinct types of adversity. In a sample of 94 children (6-19 years), we investigated whether experiences of material deprivation, emotional deprivation, and trauma have differential associations with reward-related behavior and white matter microstructure in tracts involved in reward processing. Material deprivation (food insecurity), but not emotional deprivation or trauma, was associated with poor reward performance. Adversity-related influences on the integrity of white matter microstructure in frontostriatal tracts varied across childhood adversity types, and reductions in frontostriatal white matter integrity mediated the association of food insecurity with depressive symptoms. These findings document distinct behavioral and neurodevelopmental consequences of specific forms of adversity that have implications for psychopathology risk.

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Grants

  1. R01 MH103291/NIMH NIH HHS
  2. R01 MH106482/NIMH NIH HHS
  3. K23 MH112872/NIMH NIH HHS
  4. F32 HD089514/NICHD NIH HHS
  5. T32 HD057822/NICHD NIH HHS

MeSH Term

Adolescent
Adverse Childhood Experiences
Child
Depressive Disorder
Emotions
Female
Food Supply
Humans
Male
Reward
White Matter
Young Adult
Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

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