Biosensors for Alzheimer's disease biomarker detection: A review.
Bingqing Shui, Dan Tao, Anca Florea, Jing Cheng, Qin Zhao, Yingying Gu, Wen Li, Nicole Jaffrezic-Renault, Yong Mei, Zhenzhong Guo
Author Information
Bingqing Shui: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, PR China. Electronic address: dorisbing@163.com.
Dan Tao: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, PR China. Electronic address: tstower@hotmail.com.
Anca Florea: Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania. Electronic address: florea.ancas@yahoo.com.
Jing Cheng: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, PR China. Electronic address: cj8402@163.com.
Qin Zhao: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, PR China. Electronic address: happyhaber@163.com.
Yingying Gu: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, PR China. Electronic address: 15872350960@163.com.
Wen Li: School of Arts, Wuhan Business University, Wuhan 430056, PR China. Electronic address: 13707162001@163.com.
Nicole Jaffrezic-Renault: Institute of Analytical Sciences, UMR-CNRS 5280, University of Lyon, 5, Rue de La Doua, Villeurbanne 69100, France. Electronic address: nicole.jaffrezic@univ-lyon1.fr.
Yong Mei: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, PR China. Electronic address: meiyong2006@163.com.
Zhenzhong Guo: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, PR China. Electronic address: zhongbujueqi@hotmail.com.
Alzheimer's disease (AD) is a chronic disease amongst people aged 65 and older. Increasing evidence has illustrated that early diagnosis holds the key to effective treatment of AD. A variety of detection techniques have been developed. Biosensors are excellent analytical tools which have applications in detecting the biomarkers of AD. This review includes appropriate bioreceptors to achieve highly sensitive and selective quantification of AD biomarkers by using transducers. AD biomarkers such as tau protein, amyloid β peptides and apolipoprotein E4, are firstly summarized. The most commonly used bioreceptors, including aptamers and antibodies, are also reviewed. We introduce aptamers specific to AD biomarkers, list the sequences of aptamers designed to capture AD biomarkers and compare the properties of aptamers with those of antibodies with regard to their efficiency as bio-recognition elements. We discuss the recent progress of aptamer systems' applications in AD biomarkers in biosensing. The review also discusses novel strategies used for signal amplification in sensing AD biomarkers.
