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Chemistry (Weinheim an der Bergstrasse, Germany)
Feb 06, 2018;24 (8): 1789-1794.

Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies.

Jingjing Gao, Xiaochi Liu, Hatice Secinti, Ziwen Jiang, Oyuntuya Munkhbat, Yisheng Xu, Xuhong Guo, S Thayumanavan
Author Information
  1. Jingjing Gao: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  2. Xiaochi Liu: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  3. Hatice Secinti: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  4. Ziwen Jiang: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  5. Oyuntuya Munkhbat: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  6. Yisheng Xu: State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
  7. Xuhong Guo: State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
  8. S Thayumanavan: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA. ORCID
PMID: 29314349 DOI: 10.1002/chem.201705217

Abstract

Specific response to the concurrent presence of two different inputs is one of the hallmarks of incorporating specificities in nature. Artificial nanoassemblies that concurrently respond to two very different inputs are of great interest in a variety of applications, especially in biomedicine. Here, we present a design strategy for amphiphilic nanoassemblies with such capabilities, enabled by photocaging a ligand moiety that is capable of binding to a specific protein. New molecular designs that offer nanoassemblies that respond to either of two inputs or only to the concurrent presence of two inputs are outlined. Such biomimetic nanoassemblies could find use in many applications, including drug delivery and diagnostics.

Keywords

dual inputs host-guest transformation photoactivation stimulus-responsive nanoassemblies supramolecular disassembly

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Grants

  1. R01 GM065255/NIGMS NIH HHS
Journal Article
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